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Proton Sensing GPCR's: The missing link to Warburg's Oncogenic Legacy?
J Cancer Biol
January 2024
Department of Medicine, Michigan State University College of Human Medicine, East Lansing, MI, USA.
Article Synopsis
- - The Warburg effect describes how cancer cells favor aerobic glycolysis, producing more lactate even with oxygen available, which leads to an acidic tumor environment that promotes cancer traits like drug resistance and immune evasion.
- - Proton-sensing G-protein-coupled receptors (GPCRs), such as GPR68, can detect this acidity and activate cancer-promoting signaling pathways, suggesting a link between the acidic environment and tumor growth mechanisms.
- - Understanding how these proton-sensing receptors relate to the Warburg effect could open up new avenues for cancer treatment by targeting the metabolic changes that favor tumor development.
Today's cancer research and treatment - highly sophisticated and molecularly targeted, yet firmly bolstered in the classical theories.
J Appl Biomed
September 2024
Medical University of Vienna, Comprehensive Cancer Center (CCC), Ludwig Boltzmann Institute for Hematology & Oncology, Department of Medicine I, Vienna, Austria.
Cancer research is linked to modern life-sciences, encompassing achievements in virology, yeast-biology, molecular-biology, genetics, systems-biology, bioinformatics, and so on. With these fascinating developments, it's easy to overlook that the fundamental theories and treatment strategies were established in the early 20th century and have remained valid ever since. Therefore, tribute must be paid to the founders of the field.
View Article and Find Full Text PDF100 years of the Warburg effect: A cancer metabolism endeavor.
Cell
July 2024
Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Herestraat 49, 3000 Leuven, Belgium. Electronic address:
If you are a scientist and you only know one thing about tumor metabolism, it's likely the Warburg effect. But who was Otto Warburg, and how did his discoveries regarding the metabolism of tumors shape our current thinking about the metabolic needs of cancer cells?
View Article and Find Full Text PDFUnlocking the role of lactate: metabolic pathways, signaling, and gene regulation in postmitotic retinal cells.
Front Ophthalmol (Lausanne)
November 2023
Departments of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
The Warburg effect, which was first described a century ago, asserts that mitotic tumor cells generate higher quantities of lactate. Intriguingly, even in typical physiological circumstances, postmitotic retinal photoreceptor cells also produce elevated levels of lactate. Initially classified as metabolic waste, lactate has since gained recognition as a significant intracellular signaling mediator and extracellular ligand.
View Article and Find Full Text PDFCanonical WNT/β-catenin signaling upregulates aerobic glycolysis in diverse cancer types.
Mol Biol Rep
July 2024
Department of Medical Oncology Lab, DR BRA IRCH, All India Institute of Medical Sciences (AIIMS), 4thFloor, Ansari Nagar, New Delhi, 110029, India.
Despite many efforts, a comprehensive understanding and clarification of the intricate connections within cancer cell metabolism remain elusive. This might pertain to intracellular dynamics and the complex interplay between cancer cells, and cells with the tumor stroma. Almost a century ago, Otto Warburg found that cancer cells exhibit a glycolytic phenotype, which continues to be a subject of thorough investigation.
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