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Genetic mutations in kinases: a comprehensive review on marketed inhibitors and unexplored targets in Parkinson's disease.
Neurol Sci
January 2025
School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar- Grand Trunk Rd, Phagwara, Punjab, India.
This comprehensive review navigates the landscape of genetic mutations in kinases, offering a thorough examination of both marketed inhibitors and unexplored targets in the context of Parkinson's Disease (PD). Although existing treatments for PD primarily center on symptom management, progress in comprehending the molecular foundations of the disease has opened avenues for targeted therapeutic approaches. This review encompasses an in-depth analysis of four key kinases-PINK1, LRRK2, GAK, and PRKRA-revealing that LRRK2 has garnered the most attention with a plethora of marketed inhibitors.
View Article and Find Full Text PDFMagnitude and associated factors of postpartum family planning uptake among postpartum women in Ethiopia: an umbrella review.
Front Glob Womens Health
December 2024
Department of Midwifery, College of Medicine and Health Science, Ariba Minch University, Ariba Minch, Ethiopia.
Background: The World Health Organization indicates that despite advancements, the rates of maternal and neonatal mortality and morbidity during the postpartum period continue to be alarmingly high. Furthermore, untapped opportunities to enhance maternal health and promote effective newborn care, including family planning services, have not been fully leveraged. Earlier meta-analyses and systematic reviews have addressed this subject; however, a thorough evidence synthesis has not been provided.
View Article and Find Full Text PDFMapping heat tolerance QTLs in backcross introgression lines to enhance thermotolerance in wheat.
Front Plant Sci
December 2024
School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, India.
Wheat, a major cereal crop, is the most consumed staple food after rice in India. Frequent episodes of heat waves during the past decade have raised concerns about food security under impending global warming and necessitate the development of heat-tolerant wheat cultivars. Wild relatives of crop plants serve as untapped reservoirs of novel genetic variations.
View Article and Find Full Text PDFSquamous cell carcinoma in rare case of Huriez Syndrome: The role of distant flaps.
JPRAS Open
March 2025
Hand and Microsurgery Unit, Jewish Hospital, Via Fulda 14, Rome 00148, Italy.
Context: Huriez syndrome is a rare de rmatological condition characterized by severe sclerotic and atrophic changes in the extremities (hands and feet) and an increased tendency to develop squamous cell carcinomas, with no established gold standard for the surgical treatment of these patients, who are difficult to manage due to the inability to perform reconstructions using local flaps.
Clinical Case: We report the case of a patient with severe Huriez syndrome who had developed SCC in both the hands and foot over time. After multiple surgeries at other centers, all resulting in recurrences, we planned wide excisions followed by reconstruction using distant flaps.
Cold-active enzymes from deep marine psychrophiles: harnessing their potential in enhanced food production and sustainability.
Crit Rev Biotechnol
January 2025
Department of Animal Biotechnology, Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju Special Self-Governing Province, Republic of Korea.
Exploring the untapped potential of deep-sea microorganisms, particularly their cold-active enzymes, or psychrozymes, offers exciting possibilities for revolutionizing various aspects of the food processing industry. This review focuses on these enzymes, derived from the largely unexplored depths of the deep ocean, where microorganisms have developed unique adaptations to extreme conditions. Psychrozymes, as bioactive molecules, hold significant promise for food industry applications.
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