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Study on the detoxification and toxic effects of clam Ruditapes philippinarum exposed to 2,6-ditert-butyl-4-methylphenol (BHT): Oxidative stress, neurotoxicity, respiratory toxicity, and immunotoxicity.
Environ Res
January 2025
The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, 266003, PR China. Electronic address:
The bioaccumulation and toxic effects of synthetic phenolic antioxidants (SPAs) in aquatic ecosystems are of growing concern due to their widespread use and potential environmental persistence. This study investigated the detoxification and toxicological impacts of 2,6-ditert-butyl-4-methylphenol (BHT), a representative SPAs, on clams Ruditapes philippinarum using environmentally relevant exposure concentrations. BHT bioaccumulation was observed in both gills and digestive glands, with higher levels in the latter.
View Article and Find Full Text PDFInvestigation of the In Vitro Antioxidant, Anticholinesterase, Antiurease, Antityrosinase, and Cytotoxic Properties of a Novel Compound: 4-Methoxy-2-(4-Methoxyphenyl)Benzo[d][1,3,2]Dioxaborole.
Pharmacol Res Perspect
February 2025
Department of Pharmacology and Toxicology, Faculty of Veterinary, Ankara University, Ankara, Turkey.
In this study, the structure of a new boron compound obtained using 3-methoxy catechol and 4-methoxy phenyl boronic acid was characterized by H, C NMR, LC-MS-IT-TOF, UV-Vis and FTIR spectroscopy. The antioxidant activities of the newly synthesized compound were evaluated by DPPH free radical scavenging, ABTS quation radical scavenging and CUPRAC copper reducing capacity methods. Anticholinesterase activities were determined by acetylcholinesterase and butyrylcholinesterase enzyme inhibitor assays.
View Article and Find Full Text PDFXylan from Dinizia excelsa: Chemical characterization and biological activities.
An Acad Bras Cienc
December 2024
Universidade Federal de Pernambuco (UFPE), Centro de Biociências, Departamento de Antibióticos, Av. Professor Moraes Rego, s/n, Cidade Universitária, 50740-600 Recife, PE, Brazil.
Dinizia Excelsa is an Amazonian tree with a wide range of applications as a raw material in the industry. The objective of this study was to extract, characterize, and evaluate the biological activities of xylan extracted from Dinizia excelsa wood. The xylan was obtained in five stages, including delignification, precipitation, purification, and freeze-drying.
View Article and Find Full Text PDFDual intervention of Boeravinone B and Chebulinic Acid mitigates BHT-Induced toxicity in HepG2 cells: modulating apoptosis and autophagy.
Sci Rep
November 2024
Department of Biochemistry, Shivaji University, Kolhapur, 416004, MS, India.
Article Synopsis
- Butylated Hydroxytoluene (BHT), commonly used as an antioxidant in food, causes cellular toxicity by inducing oxidative stress and increasing reactive oxygen and nitrogen species (ROS and RNS).
- The herbal compounds Boeravinone B (BB) and Chebulinic acid (CA), when combined, showed significant protective effects against BHT’s toxicity by reducing levels of ROS and RNS, as well as decreasing enzymes and markers associated with oxidative stress.
- The treatment with BB and CA effectively reduced apoptosis and autophagy in cells exposed to BHT, promoting cell growth and suggesting their potential use as therapeutic agents for conditions related to oxidative stress-induced liver damage.
Assessment of the relative cardiotoxicity and behavioral effects of butylated hydroxytoluene and its metabolites in developing zebrafish (Danio rerio).
Sci Total Environ
December 2024
Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida Genetics Institute, Interdisciplinary Program in Biomedical Sciences Neuroscience, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.
Butylated hydroxytoluene (BHT) and its transformation products are ubiquitously detected in aquatic environments. Despite studies reporting on the adverse effects of BHT exposure in early-staged zebrafish, the comparative toxicity of its metabolites is not known. To address this, zebrafish embryos were exposed continuously to 0.
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