Infection by bacterial products in the implant and endotoxin introduced by wear particles activate immune cells, enhance pro-inflammatory cytokines production, and ultimately promote osteoclast recruitment and activity. These factors are known to play an important role in osteolysis as well as potential targets for the treatment of osteolysis. Sesamin has been shown to have a variety of biological functions, such as inhibiting inflammation, anti-tumour and involvement in the regulation of fatty acid and cholesterol metabolism. However, the therapeutic effect of sesamin on osteolysis and its mechanism remain unclear. Present studies shown that in the condition of in vitro, sesamin could inhibit osteoclastogenesis and bone resorption, as well as suppressing the expression of osteoclast-specific genes. Further studies on the mechanism suggest that the effect of sesamin on human osteoclasts was mediated by blocking the ERK and NF-κB signalling pathways. Besides, sesamin was found to be effective in treating LPS-induced osteolysis by decreasing the production of pro-inflammatory cytokines and inhibiting osteoclastogenesis in vivo. Sesamin was non-toxic to heart, liver, kidney, lung and spleen. Therefore, sesamin is a promising phytochemical agent for the therapy of osteolysis-related diseases caused by inflammation and excessive osteoclast activation.
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http://dx.doi.org/10.1111/jcmm.18056 | DOI Listing |
J Appl Microbiol
January 2025
School of Basic Medicine, Jiamusi University, Jiamusi 154000, China.
Aims: The aim of this study was to identify sesamin as a Casein hydrolase P (ClpP) inhibitor and to determine whether it could attenuate the virulence of methicillin-resistant Staphylococcus aureus (MRSA).
Methods And Results: Through fluorescence resonance energy transfer (FRET) screening, a natural compound sesamin demonstrated a significant inhibitory effect on ClpP enzyme activity with an IC50 of 20.62 μg/mL.
J Agric Food Chem
January 2025
College of Food Science and Engineering, Key Laboratory of Food Nutrition and Human Health in Universities of Shandong, Shandong Agricultural University, Taian 271018, China.
Food allergens are the key triggers of allergic diarrhea, causing damage to the immune-rich ileum. This weakens the mucosal barrier and tight junctions, increases intestinal permeability, and exacerbates allergen exposure, thereby worsening the condition. Sesamin, a natural lignan isolated from sesame seed, has shown potential in regulating immune responses, but its effects on intestinal health remain unclear.
View Article and Find Full Text PDFFront Nutr
December 2024
School of Public Health, Shandong Second Medical University, Weifang, China.
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a common chronic disease seriously threatening human health, with limited treatment means, however. Sesamin, a common lignan in sesame seed oil, exhibits anti-inflammatory, antioxidant, and anticancer properties. Our previous studies have shown an ameliorative effect of sesamin on lipid accumulation in human hepatocellular carcinoma (HePG2) induced by oleic acid, with its protective effects unclear in the case of 9-trans-C18:1 elaidic acid (9-trans-C18,1).
View Article and Find Full Text PDFHeliyon
October 2024
Institute of Applied Science and Technology, College of Basic and Applied Sciences, University of Ghana, Legon, Ghana.
The sesame seed contains oil, protein, dietary fibre, and several minerals and it is also a store of lignans. Lignans are key selection factors for sesame quality due to their health, nutritive and market value. In Ghana sesame growers rely on wild or undocumented planting seeds which are of mixed colouration and its lignan content is ambiguous.
View Article and Find Full Text PDFChem Biodivers
November 2024
Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India.
Malaria is an infectious disease, endemic to tropical and sub-tropical regions causing half a million people's deaths every year. Bioactive compounds derived from medicinal plants are used to treat malaria disease and its complications. H.
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