Visible light-enabled synthesis of phosphorylated indolizine and pyridoindole derivatives HAT-mediated radical cascade cyclization.

A visible light-enabled cascade cyclization strategy is disclosed with concomitant phosphorylation and heterocycle construction. It provides a novel and environmentally benign approach for accessing tetrahydroindolizine-containing phosphonates under metal-free conditions. Mechanistic studies revealed that phosphinoyl radicals were generated from H-phosphonates a HAT process.