AI Article Synopsis
- Carbapenem-resistant Enterobacteriaceae (CRE) pose a serious public health threat, necessitating investigation through genomic sequencing.
- Data was collected from nine U.S. clinical laboratories between 2013 and 2016, involving 680 isolates of both CRE and carbapenem-susceptible Enterobacteriaceae (CSE).
- The study examined the molecular epidemiology and antimicrobial susceptibility testing (AST) of these isolates, providing valuable data for understanding resistance patterns and aiding future research in antimicrobial resistance.
Article Abstract
Carbapenem-resistant (CRE) are an urgent public health threat. Genomic sequencing is an important tool for investigating CRE. Through the Division of Healthcare Quality Promotion Sentinel Surveillance system, we collected CRE and carbapenem-susceptible (CSE) from nine clinical laboratories in the USA from 2013 to 2016 and analysed both phenotypic and genomic sequencing data for 680 isolates. We describe the molecular epidemiology and antimicrobial susceptibility testing (AST) data of this collection of isolates. We also performed a phenotype-genotype correlation for the carbapenems and evaluated the presence of virulence genes in complex isolates. These AST and genomic sequencing data can be used to compare and contrast CRE and CSE at these sites and serve as a resource for the antimicrobial resistance research community.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10711308 | PMC |
| http://dx.doi.org/10.1099/mgen.0.001119 | DOI Listing |
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