House dust mite (HDM)-allergic asthma is an abnormal immune response to extrinsic aeroallergens found in human vicinities. Studying the role of the associated immunity biomarkers and their interplay helps in discovering novel therapeutic strategies that can be used in adjunct with effective long-term immunotherapy. This study investigates the total serum IgE, FoxO1, and Sirtuin 1 (SIRT1) gene expressions in HDM-allergic asthma patients. We enrolled 40 patients for each of the following three groups: an HV group of healthy volunteers and HDM/AA and HDM/SCIT groups of HDM-allergic asthma patients who did not and who did receive immunotherapy before recruitment in this study, respectively. The results elucidated that total IgE was strikingly elevated in the HDM/AA group and showed little decline in the HDM/SCIT group. Both FoxO1 and SIRT1 gene expressions showed the highest levels in the HDM/SCIT group. There was a negative correlation between total IgE and both FoxO1 and SIRT1 in the HDM/AA group while there was a positive correlation with SIRT1 in the HDM/SCIT group. In conclusion, the interplay of the three immunity biomarkers related to HDM-allergic asthma after the course of immunotherapy treatment suggests further, broader studies on the feasibility of their role as immunity biomarkers in the control and remission of HDM-allergic asthma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660720 | PMC |
| http://dx.doi.org/10.3390/arm91060039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synbiotics, a promising approach for alleviating exacerbated allergic airway immune responses in offspring of a preclinical murine pollution model.
Environ Toxicol Pharmacol
December 2024
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands; Danone Nutricia Research, Utrecht, Netherlands. Electronic address:
Article Synopsis
- - The study investigates how synbiotic supplements can help reduce allergic asthma symptoms in offspring exposed to environmental cigarette smoke and house-dust mites.
- - Researchers found that pups from mothers exposed to cigarette smoke had increased lung resistance and elevated immune markers, indicating worse asthma symptoms, but synbiotics helped improve these conditions.
- - By promoting healthy gut bacteria, synbiotic intervention in early life showed promise in reducing allergic reactions and suggests a potential strategy for preventing allergies in children affected by pollution.
Background: Allergen immunotherapy (AIT) aims at modulating the immune response by administration of allergen preparations at regular intervals over several years (1). For subcutaneous AIT (SCIT), the treatment is initiated with a dose escalation phase followed by a maintenance dose administration. Over the last decade, there has been a trend towards shortening dose escalation regimens to increase patient adherence.
View Article and Find Full Text PDFA large scale multicentre randomized, placebo-controlled subcutaneous house dust mite allergen immunotherapy (HDM SCIT) in allergic rhinitis: MITAR Study.
Asian Pac J Allergy Immunol
September 2024
Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University; and the King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Background: Previous house dust mite subcutaneous immunotherapy (HDM SCIT) placebo-controlled trials have small sample sizes and lack a consensus on baseline treatment.
Objective: To determine the efficacy of HDM SCIT in moderate-to-severe allergic rhinitis (AR) patients treated with an intranasal corticosteroid at baseline.
Methods: We conducted a randomized, placebo-controlled trial comparing HDM SCIT against placebo in Dermatophagoides pteronyssinus (Der p) sensitized.
Optimization of Basophil Activation Test in the Diagnosis and Qualification for Allergen-Specific Immunotherapy in Children with Respiratory Allergy to the House Dust Mite .
Int J Mol Sci
September 2024
Centre of Clinical and Environmental Allergology, Jagiellonian University Medical College, 31-503 Krakow, Poland.
Article Synopsis
- - The study optimized a basophil activation test (BAT) to improve detection of house dust mite (HDM) allergy in children with allergic respiratory diseases, involving 32 children (13 girls and 19 boys) aged 4-17, and a control group of 32 children with other types of allergies.
- - The BAT was conducted using various allergen concentrations to determine the best cut-off point for distinguishing between HDM-allergic and non-allergic individuals, finding that a cut-off of 9.76% activated basophils at 2.25 ng/mL yielded high sensitivity (90.6%) and perfect specificity (100%).
- - The results were highly consistent with other allergy testing methods, showing strong
[Molecular allergen IgE tests show neosensitizaions occurring during house dust mite specific immunotherapy].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2024
Neosensitizations may be occur during the allergen specific immunotherapy（AIT） due to the differences between allergen vaccine's content and a patient's molecular sensitization profile. This study investigates whether AIT with HDM extract changes the sensitization profile, whether de novo sensitization occurs, and the clinical importance of the neosensitization. Fifty-three patients with HDM allergic rhinitis ,with/without asthma, patients were received one year HDM subcutaneous AIT .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!