Objectives: To investigate the association between maternal early pregnancy body mass index (BMI) and offspring bipolar disorder (BPD).
Methods: We conducted a nationwide cohort study among 1,507,056 non-malformed singleton live-births in Sweden born 1983-2004. Using national registries with prospectively recorded information, we followed participants for a BPD diagnosis from ages 13 to up to 35 years. We compared BPD risks by early pregnancy BMI using hazard ratios (HR) with 95% confidence intervals (CI) from adjusted Cox models. We also conducted sibling-controlled analyses among 874,047 full siblings.
Results: There were 9970 BPD diagnoses. Risk of BPD was 0.72% through 25 years of age. Maternal early pregnancy BMI was positively associated with offspring BPD risk. Compared with normal BMI (18.5-24.9), adjusted HR (95% CI) for overweight (BMI 25-29.9), obesity grade 1 (BMI 30-34.9), and obesity grades 2-3 (BMI ≥35) were 1.08 (1.02, 1.15), 1.26 (1.14, 1.40), and 1.31 (1.07, 1.60), respectively. Adjusted HR per unit BMI was 1.015 (95% CI 1.009, 1.021). A similar trend was observed among siblings. Pregnancy and neonatal complications did not substantially mediate the association between maternal obesity (BMI ≥30) and offspring BPD.
Conclusions: Maternal BMI ≥25 is associated with offspring BPD risk in a dose-response manner.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102928 | PMC |
| http://dx.doi.org/10.1111/bdi.13399 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The integration of telehealth into maternal and child health (MCH) care presents an opportunity to enhance health equity, offering solutions to bridge gaps in access and quality of care. This paper explores the impact and reach of telehealth services on MCH, emphasizing its potential to address disparities in healthcare access, particularly for underserved and marginalized populations. Telehealth facilitates improved access to care by reducing geographical barriers, offering convenient and flexible consultation options, and providing cost-effective solutions for low-income families.
View Article and Find Full Text PDFMagnitude and factors associated with low birth weight among newborns in public health facilities of Mekelle City, northern Ethiopia: a multi-center study.
Front Pediatr
December 2024
Department of Midwifery, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Background: Low birth weight is a key determinant of child survival, significantly influencing rates of infant and childhood mortality, morbidity, and disability. While some studies have been conducted in our region, there is still a gap in evidence regarding the maternal characteristics associated with low birth weight. Hence, this study aimed to determine the proportion of newborns with low birth weight and determinant factors, particularly focusing on maternal characteristics.
View Article and Find Full Text PDFAssociation between diet quality during pregnancy of mothers and that of 3-year-old offspring: a prospective hospital-based birth cohort study.
J Nutr Sci
August 2024
Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
Children's eating habits are established early in life and parents play a major role therein. Pregnancy is a teachable moment for the promotion of healthy eating because many women are concerned about their babies' health and have frequent contact with healthcare providers. We aimed to investigate the association between diet quality during pregnancy and the offspring.
View Article and Find Full Text PDFEmbryoscopy and targeted embryo biopsy for the management of early abortion.
J Assist Reprod Genet
January 2025
Centro de Asistencia a La Reproducción Humana de Canarias, La Laguna, Santa Cruz de Tenerife, Spain.
Purpose: To evaluate the safety, accuracy, and effectiveness of embryoscopy for the management of early abortion and to test the hypothesis that targeted embryo and chorionic villi sampling avoids maternal cell contamination (MCC) for genetic testing of products of conception (POC).
Methods: This ambispective study included 74 consecutive patients presenting with early abortion. Gestations between 5 and 9 weeks, obtained either spontaneously or through assisted reproductive technologies were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!