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Synaptic mechanisms for associative learning in the cerebellar nuclei. | LitMetric

Synaptic mechanisms for associative learning in the cerebellar nuclei.

Nat Commun

Department of Cerebellar Coordination and Cognition, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

Published: November 2023

AI Article Synopsis

  • Associative learning in delay eyeblink conditioning (EBC) relies heavily on the cerebellum, raising questions about how cerebellar nuclei contribute to this learning process.
  • Research shows that stimulating mossy fiber inputs can act as a conditioned stimulus, effectively prompting well-timed conditioned responses in mice.
  • Structural changes in synaptic inputs occur during EBC, specifically in mossy fibers and inhibitory inputs, which enhance the processing abilities of cerebellar nuclei neurons, thereby supporting learning and adaptive responses.

Article Abstract

Associative learning during delay eyeblink conditioning (EBC) depends on an intact cerebellum. However, the relative contribution of changes in the cerebellar nuclei to learning remains a subject of ongoing debate. In particular, little is known about the changes in synaptic inputs to cerebellar nuclei neurons that take place during EBC and how they shape the membrane potential of these neurons. Here, we probed the ability of these inputs to support associative learning in mice, and investigated structural and cell-physiological changes within the cerebellar nuclei during learning. We find that optogenetic stimulation of mossy fiber afferents to the anterior interposed nucleus (AIP) can substitute for a conditioned stimulus and is sufficient to elicit conditioned responses (CRs) that are adaptively well-timed. Further, EBC induces structural changes in mossy fiber and inhibitory inputs, but not in climbing fiber inputs, and it leads to changes in subthreshold processing of AIP neurons that correlate with conditioned eyelid movements. The changes in synaptic and spiking activity that precede the CRs allow for a decoder to distinguish trials with a CR. Our data reveal how structural and physiological modifications of synaptic inputs to cerebellar nuclei neurons can facilitate learning.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662440PMC
http://dx.doi.org/10.1038/s41467-023-43227-wDOI Listing

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