AI Article Synopsis
- The research aims to understand how stress affects brain function and contributes to psychiatric disorders, but effective medications targeting these biological changes are still insufficient.
- Factors like study design, individual differences, gender variations, and the body's natural rhythms may complicate stress research and hinder the development of new treatments.
- The authors emphasize the need to address these complexities in stress neurobiology to better evaluate stress mechanisms and apply research findings to clinical settings.
Article Abstract
Among the central goals of stress neurobiology research is to understand the mechanisms by which stressors change neural circuit function to precipitate or exacerbate psychiatric symptoms. Yet despite decades of effort, psychiatric medications that target the biological substrates of the stress response are largely lacking. We propose that the clinical advancement of stress response-based therapeutics for psychiatric disorders may be hindered by 'hidden variables' in stress research, including considerations of behavioral study design (stressors and outcome measures), individual variability, sex differences, and the interaction of the body's stress hormone system with endogenous circadian and ultradian rhythms. We highlight key issues and suggest ways forward in stress neurobiology research that may improve the ability to assess stress mechanisms and translate preclinical findings.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842876 | PMC |
| http://dx.doi.org/10.1016/j.tins.2023.10.006 | DOI Listing |
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