AI Article Synopsis
- Oral probiotic therapy is gaining popularity for treating diseases like intestinal barrier dysfunction, IBD, and colorectal cancer due to its safety and convenience.
- However, many probiotics struggle to survive the harsh conditions of the gastrointestinal tract and effectively colonize the colon.
- The review highlights advancements in single-cell modification strategies to enhance probiotic delivery systems, address their limitations, and improve therapeutic efficacy for conditions like colitis.
Article Abstract
Oral probiotic therapy has become an increasingly attractive method for treating various diseases, including intestinal barrier dysfunction, inflammatory bowel disease (IBD), and colorectal cancer due to its safety and convenience. However, only a few probiotics after oral gavage can survive the acidic and bile salt conditions of the gastrointestinal tract and colonize the colon to have a nutritional effect on the host. To address these challenges, encapsulation technology has been applied to protect probiotics from harsh gastrointestinal conditions, improve gut adhesion, and reduce immunogenicity. In addition, some of the functional polysaccharides are used to endow probiotics with exogenous functions as prebiotics. In this review, we systematically introduced the advancements of emerging single-cell modification strategies for probiotics in IBD applications. Additionally, we discussed the limitations and perspectives of single-cell modification strategies for probiotics. This review contributed to the development of probiotic delivery systems with higher therapeutic efficacy against colitis.
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| http://dx.doi.org/10.1016/j.carbpol.2023.121472 | DOI Listing |
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