AI Article Synopsis
- * These growths are usually found on the cusps of the aortic and pulmonary valves, leading to differing opinions on their role in thromboembolic events.
- * In a study of 403 healthy human hearts, this research found that the prevalence and characteristics of LEs were significantly lower than the previously reported rates of 85-90%.
Article Abstract
Lambl excrescences (LEs) were initially described in the mid-1800s during autopsies of human hearts, and their significance and biology have been debated ever since. LEs are typically found on aortic and pulmonary valve (semilunar) cusps. There is debate concerning whether LEs are a significant cause of thromboembolic events, or whether they are harmless growths. However, there have not been many reports discussing LEs, and fewer still have examined the prevalence and characteristics of LEs in healthy human hearts. Those who have examined LE prevalence have reported a very high incidence of LEs (85-90%). Herein, we examine LE prevalence and characteristics (size, location, number) in 403 healthy human hearts across all age groups. We find that the prevalence of LEs in healthy hearts is far lower than previously reported.
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| http://dx.doi.org/10.1016/j.carpath.2023.107588 | DOI Listing |
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