AI Article Synopsis
- Male reproduction is affected by dietary factors, particularly through high-fat and low-protein diets, but the effects of low-fat, high-carb diets on sperm traits are less understood.
- This study aimed to assess how replacing glucose with fructose in various fat content diets influences sperm characteristics in male mice.
- The findings indicate that while higher fat diets increase body weight and sperm production, they can decrease motility, suggesting that tailored dietary recommendations could help improve male fertility rather than a one-size-fits-all approach.
Article Abstract
Background: Male reproduction is impacted by both over- and under-nutrition, demonstrated by animal studies using high-fat and low-protein dietary interventions. Little is known about the impacts of low-fat, high-carb diets and types of dietary carbohydrates on sperm traits.
Objectives: Using a nutritional geometry approach, we investigated the effects of partially or completely substituting glucose for fructose in isocaloric diets containing either 10%, 20%, or 30% fat (by energy) on sperm traits in mice.
Methods: Male C57BL/6J mice were fed 1 of 15 experimental diets for 18 wk starting from 8 wk of age. Reproductive organs were then harvested, and sperm concentration, motility, and velocity were measured using Computer-Assisted Sperm Analysis.
Results: Increasing dietary fat from 10% to 30% while maintaining energy density at 14.3 kJ/g and protein content at 20% resulted in increased body weight and sperm production but reduced the percentage of motile sperm. Body weight and seminal vesicle weight were maximized on diets containing a 50:50 mix of fructose and glucose, but carbohydrate type had few significant impacts on epididymal sperm traits.
Conclusions: The opposing impacts of dietary fat on mouse sperm quantity and quality observed suggest that male fertility may not be optimized by a single diet; rather, context-specific dietary guidelines targeted to specific concerns in semen quality may prove useful in treating male infertility.
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| http://dx.doi.org/10.1016/j.tjnut.2023.11.016 | DOI Listing |
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