Objectives: To investigate the association between metabolic syndrome (MetS) and anxiety and to explore the mediating role of inflammation indicators in this relationship based on the UK Biobank prospective cohort.
Methods: This population-based retrospective cohort study analyzed data from 308,352 participants. MetS was defined according to criteria jointly developed by the American Heart Association, the National Heart, Lung, and Blood Institute, and the International Diabetes Federation. Anxiety was defined using ICD-10 codes. Cox proportional risk regression models were used to explore the hazard ratios (HRs) between MetS, components of MetS, number of MetS components, and anxiety. The mediating effect of inflammation on the association between MetS and anxiety was explored using longitudinal mediation analysis.
Results: A total of 308,352 participants were included in this study. Of these, 9471 (3.071 %) developed anxiety over a mean follow-up of 12.05 years. In the fully adjusted model, MetS increased the risk of anxiety by 13.6 % (HR: 1.136, 95 %CI: 1.085-1.189). All MetS components significantly increased the risk of anxiety, with HRs ranging from 1.066 to 1.165. When MetS was treated as a linear variable, the risk of anxiety increased by 6.5 % per component increment. Age-stratified results showed that the risk of MetS for anxiety was higher among those <55 years (HR: 1.23, 95 %CI: 1.13-1.33) than among those ≥55 years (HR: 1.12, 95 %CI: 1.06-1.18). The mediating effects of platelets, lymphocytes, neutrophils, C-reactive protein, leukocytes, and INFLA scores on the association between MetS and anxiety were significant, with mediating effects of 2.30 %, 7.20 %, 15.9 %, 20.7 %, 22.0 %, and 25.3 %, respectively, and a combined mediating effect of these inflammatory factors was 30.8 % (except for INFLA scores).
Conclusions: MetS and its components significantly increased the risk of anxiety, which increased with the number of components. This association may be partially mediated by serum inflammatory indicators, suggesting that MetS may increase the risk of anxiety by elevating the level of chronic inflammation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbi.2023.11.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction: Those with established symptomatic cardiopulmonary disease should attend secondary prevention programs. Attendance at these programs is known to differ by sex and by smoking status, with females and those who smoke being less likely to attend. However, little is known about whether the risk factors of being female and smoking are cumulative, and how outcomes from secondary prevention differ by these subgroups.
View Article and Find Full Text PDFAre abnormalities in lipid metabolism, together with adverse childhood experiences, the silent causes of immune-linked neurotoxicity in major depression?
Neuro Endocrinol Lett
December 2024
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Background: Severe or recurring major depression is associated with increased adverse childhood experiences (ACEs), heightened atherogenicity, and immune-linked neurotoxicity (INT). Nevertheless, the interconnections among these variables in outpatient major depression (OMDD) have yet to be determined. We aim to determine the correlations among INT, atherogenicity, and ACEs in OMDD patients compared to normal controls.
View Article and Find Full Text PDFEvaluating the impact of bioenergy economy-based health improvement (BEHI) as a mind-body intervention on laboratory, clinical and psychological factors in post-MI patients: A randomized controlled trial.
ARYA Atheroscler
January 2024
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Patients with ischemic heart disease often exhibit various psychological factors that increase the risk of future cardiovascular events. Therefore, in addition to rehabilitation programs, there is a need for more interventional psychotherapy. Bioenergy Economy-based Health Improvement (BEHI) is a mind-body intervention that may address these issues.
View Article and Find Full Text PDFOptimal intensity and dose of exercise to improve university students' mental health: a systematic review and network meta-analysis of 48 randomized controlled trials.
Eur J Appl Physiol
December 2024
Institute of Physical Education, Xinjiang Normal University, Urumqi, 830054, Xinjiang, China.
Background: A systematic evaluation and network meta-analysis (NMA) using randomized controlled trials (RCTs) was conducted to investigate the effects of different exercise intensities and dosages on the mental health of college students.
Methods: A systematic search of eight electronic databases of RCTs involving mental health exercise interventions for college students was conducted, which included data from the inception of the databases through July 2024. Two independent reviewers assessed the quality of the literature.
Metabolic syndrome patterns by gender in major depressive disorder.
PLoS One
December 2024
Department of Psychiatry, Wuhan Mental Health Center, Wuhan, China.
Article Synopsis
- - The study investigates how major depressive disorder (MDD) and metabolic syndrome (MetS) relate to each other in male and female patients hospitalized for MDD, focusing on gender-specific patterns in their clinical presentation and risk factors.
- - A total of 1,281 patients were analyzed, revealing similar prevalence rates of MetS across genders (8.21% in males and 10.34% in females), but identifying distinct risk factors: anxiety symptoms in men and age at onset as well as marital status in women.
- - Findings emphasize the necessity for targeted interventions, particularly for older, married women and older men with anxiety, as these groups showed a higher influence of gender-specific factors on MetS severity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!