AI Article Synopsis
- Endogenous Cushing's syndrome is a condition caused by excessive glucocorticoid secretion, leading to various health issues and a higher risk of mortality, even with treatment.
- Recent advances in understanding molecular mechanisms and genetic factors have improved diagnosis and treatments, but managing the syndrome remains complex.
- Surgery is the primary treatment option, but new medications have emerged; ongoing comorbidities can still affect patients' quality of life, highlighting the need for early diagnosis and effective management strategies.
Article Abstract
Endogenous Cushing's syndrome results from excess glucocorticoid secretion, which leads to a myriad of clinical manifestations, comorbidities, and increased mortality despite treatment. Molecular mechanisms and genetic alterations associated with different causes of Cushing's syndrome have been described in the last decade. Imaging modalities and biochemical testing have evolved; however, both the diagnosis and management of Cushing's syndrome remain challenging. Surgery is the preferred treatment for all causes, but medical therapy has markedly advanced, with new drug options becoming available. Nevertheless, several comorbidities remain even after patient remission, which can affect quality of life. Accurate and timely diagnosis and treatment are essential for mitigating chronic complications of excess glucocorticoids and improving patient quality of life. In this Seminar, we aim to update several important aspects of diagnosis, complications, and treatment of endogenous Cushing's syndrome of all causes.
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| http://dx.doi.org/10.1016/S0140-6736(23)01961-X | DOI Listing |
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