A 63-year-old woman presented with ruptured giant ICA terminus aneurysm, temporized with coil embolization and definitively treated with parent vessel sacrifice and high-flow bypass.
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Zoom71 navigation: Does tip orientation matter?
Clin Neurol Neurosurg
December 2024
Department of Neurosurgery, JFK University Medical Center, Edison, NJ, USA.
Background: Aspiration thrombectomy is one of the mainstays for stroke interventions. The Zoom 71 (Z71) aspiration catheter is unique with its angled tip. This study describes the orientation of the angled tip as it is navigated around the carotid siphon in relation to trackability.
View Article and Find Full Text PDFSCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms.
Br J Pharmacol
November 2024
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Background And Purpose: Metabotropic glutamate receptor 1 (mGlu) is a promising therapeutic target for neurodegenerative CNS disorders including spinocerebellar ataxias (SCAs). Clinical reports have identified naturally-occurring mGlu mutations in rare SCA subtypes and linked symptoms to mGlu mutations. However, how mutations alter mGlu function remains unknown, as does amenability of receptor function to pharmacological rescue.
View Article and Find Full Text PDFThe C-terminus of Rad is required for membrane localization and L-type calcium channel regulation.
J Gen Physiol
September 2024
Department of Physiology, University of Kentucky, Lexington, KY, USA.
L-type CaV1.2 current (ICa,L) links electrical excitation to contraction in cardiac myocytes. ICa,L is tightly regulated to control cardiac output.
View Article and Find Full Text PDFThrombectomy using Zoom Reperfusion System in pediatric acute ischemic strokes: Case series and literature review.
Neuroradiol J
May 2024
Department of Neurosurgery, The Oklahoma University Health Sciences Center, USA.
Introduction: Zoom reperfusion system (Imperative Care, CA) has proven to be promising for use in adult mechanical thrombectomies (MTs) but has not been described in pediatrics. We present two cases of a 14-year-old with acute right middle cerebral artery (MCA) syndrome and a 10-year old with acute left MCA syndrome who underwent MT using Zoom Reperfusion System safely with TICI 2B and TICI 3 recanalization, respectively.
Method: Case report and literature review.
Vessel wall imaging in the diagnosis of antiphospholipid syndrome presenting as Moyamoya syndrome-A case report.
Neuroradiol J
April 2024
Department of Radiology, University of Pennsylvania, USA.
Article Synopsis
- - A 37-year-old woman diagnosed with anti-phospholipid syndrome (APLS) exhibited symptoms of dizziness and weakness, leading to a comprehensive evaluation for stroke that included various imaging techniques.
- - Neuroimaging revealed significant ischemic damage, including an infarction in the right basal ganglia and severe narrowing of critical arteries, consistent with Moyamoya syndrome (MMS).
- - The patient received long-term anticoagulation treatment and underwent a surgical bypass, highlighting unique vessel wall MRI findings associated with APLS and its role in the development of MMS.
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