A mild chlorocyclization of pyrrole-tethered indoles has been realized using POCl as the chlorine source and tetramethylene sulfoxide as the promoter. A variety of chlorinated indolizino[8,7-]indole derivatives have been constructed efficiently under this reaction system in moderate to good yields (19 examples, up to 93% yield).
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| http://dx.doi.org/10.1021/acs.joc.3c01912 | DOI Listing |
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