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Zuranolone for postpartum depression: a systematic review and meta-analysis of two randomized studies.
Rev Bras Ginecol Obstet
December 2024
Beaumont Hospital Department of Gynaecology Dublin Ireland Department of Gynaecology, Beaumont Hospital, Beaumont Rd, Dublin, Ireland.
Article Synopsis
- The study aimed to assess the effectiveness and safety of zuranolone, an oral medication for postpartum depression (PPD), by comparing it to a placebo in randomized trials.
- A systematic search identified 11 relevant papers, leading to a detailed analysis of 2 studies involving 346 women, where zuranolone showed significant improvements in depression symptoms and reduced need for other antidepressants.
- While zuranolone appeared to be safe and effective for treating PPD, concerns about increased sedation risk necessitate further investigation.
Drug therapy versus placebo or usual care for comatose survivors of cardiac arrest; a systematic review with meta-analysis.
Resuscitation
December 2024
Regional Intensive Care Unit, Royal Victoria Hospital, 274 Grosvenor Road, Belfast, UK; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, UK. Electronic address:
Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes.
View Article and Find Full Text PDFAdverse events associated with early initiation of Eplerenone in patients hospitalized for acute heart failure.
Int J Cardiol
November 2024
Cardiovascular Research and Development Center, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, Porto, Portugal; Heart Failure Clinic, Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Gaia, Portugal; Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.
Article Synopsis
- The HEART study examined the effects of eplerenone, a mineralocorticoid receptor antagonist, in patients hospitalized for acute heart failure (HF) over 6 months, highlighting concerns about potential adverse events like worsening renal function and hyperkalemia.
- Among 297 participants, notable adverse events were recorded, but eplerenone did not significantly raise their occurrence compared to placebo, suggesting it is a safe option for HF treatment.
- Certain patient characteristics, such as older age and existing health conditions, were linked to a higher risk of adverse events, but these factors did not diminish the benefits of eplerenone on overall outcomes.
Sex hormone trajectories and association to outcomes after out-of-hospital cardiac arrest.
Resuscitation
October 2024
Emergency Medicine, University of Illinois Chicago College of Medicine, United States; Center for Advanced Resuscitation Medicine, University of Illinois Chicago College of Medicine, United States.
Background: Outcomes and susceptibility to out-of-hospital cardiac arrest (OHCA) are known to differ by sex, yet little is known about changes in sex hormones after OHCA. We sought to determine the trajectory of sex hormones after OHCA and their association to survival and neurological outcome.
Methods: Plasma samples were collected from those that survived to hospital admission at four time points (1, 6, 24, and 48 h) and estrone, estradiol, progesterone, and testosterone concentrations were quantified via liquid chromatography-mass spectrometry.
Inflammatory response after prehospital high-dose glucocorticoid to patients resuscitated from out-of-hospital cardiac arrest: A sub-study of the STEROHCA trial.
Resuscitation
September 2024
Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine - University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- The STEROHCA trial studied the effect of high-dose glucocorticoids on inflammation in patients who suffered out-of-hospital cardiac arrest (OHCA), showing promising results in reducing inflammatory markers.
- In a sample of 137 OHCA patients, those who received glucocorticoids had improved anti-inflammatory responses compared to the placebo group, with survival rates of 75% vs. 64% at 180 days.
- The treatment significantly reduced several pro-inflammatory cytokines within 24 hours of administration, indicating potential benefits of glucocorticoids in managing post-cardiac arrest syndrome.
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