AI Article Synopsis
- - Pharmacologic ascorbate is being explored as a new treatment option for glioblastoma (GBM), a type of brain tumor.
- - The study highlights how MRI can be used to assess abnormal iron metabolism in GBM, which could help enhance the effectiveness of traditional chemoradiotherapy.
- - The authors discuss the implications of their findings and outline future research directions to further develop this approach.
Article Abstract
In this CCR Translations, we discuss pharmacologic ascorbate as a novel therapeutic for glioblastoma (GBM). Aberrant iron metabolism in GBM can be assessed noninvasively by MRI and exploited to potentially improve the efficacy of chemoradiotherapy. We contextualize the study's results and discuss the next steps to further develop this paradigm. See related article by Petronek et al., p. 283.
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| http://dx.doi.org/10.1158/1078-0432.CCR-23-3027 | DOI Listing |
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