AI Article Synopsis
- Connexins are essential for creating gap junctions that link cells, and connexin 43 has been a focus in cancer research.
- The study analyzed 16 dermatofibromas (DFs) and 13 dermatofibrosarcoma protuberans (DFSP) using immunohistochemistry to assess connexin expression.
- Results showed connexin 43 was present in all DFs but absent in DFSPs, suggesting its loss may relate to the aggressive behavior of DFSP and highlight potential therapeutic targets.
Article Abstract
Connexins play a crucial role in the formation of gap junctions that connect cells to each other, as well as cells to the surrounding environment. In recent years, connexin 43 has been extensively studied in various human tumors. In this study, we conducted an immunohistochemical analysis to evaluate the expression of connexin in 16 dermatofibromas (DFs) and 13 dermatofibrosarcoma protuberans (DFSP). Connexin was diffusely expressed in the cytoplasm of all DFs with moderate or strong intensity, whereas all DFSPs showed negative staining. In addition to its diagnostic implications, the loss of Cx43 may elucidate the invasive capacity of DFSP and offer a potential avenue for future therapeutic interventions.
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| http://dx.doi.org/10.1097/DAD.0000000000002562 | DOI Listing |
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