Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654808 | PMC |
| http://dx.doi.org/10.1002/mdc3.13889 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effects of gabapentin and pregabalin on fracture healing: A histological, radiological, and biomechanical analysis.
Jt Dis Relat Surg
January 2025
Balıkesir Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, 10185 Altıeylül, Balıkesir, Türkiye.
Objectives: This study evaluated the impact of different doses of gabapentin and pregabalin on fracture healing in a rat femoral shaft model, with histological, radiological, and biomechanical assessments.
Materials And Methods: Seventy male Wistar albino rats were divided into five groups: control, low-dose gabapentin (GBP-L, 300 mg/day), high-dose gabapentin (GBP-H, 3600 mg/day), low-dose pregabalin (PRG-L, 150 mg/day), and high-dose pregabalin (PRG-H, 600 mg/day), based on human equivalent doses. Bilateral femoral fractures were induced; the right femurs were prepared for radiological examination using microtomography, followed by histological analysis, whereas the left femurs were allocated for biomechanical testing.
A randomized, double-blind, placebo-controlled clinical trial to evaluate pregabalin efficacy in the treatment of behavioral and psychological symptoms of dementia in patients with Alzheimer's disease.
Front Neurosci
November 2024
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Background: Behavioral and Psychological Symptoms of Dementia (BPSD) are common during Alzheimer's disease and cause severe problems for patients and their caregivers.
Objectives: To assess the therapeutic efficacy of Pregabalin in comparison with a placebo in treating BPSD in patients with Alzheimer's disease (AD) visiting the memory and cognition clinic of Roozbeh Psychiatric Hospital in Tehran, Iran.
Methods: A 12-week double-blind, randomized comparison of Pregabalin and placebo treatments was conducted in 53 patients with DSM-V diagnosis of dementia of Alzheimer's type.
New Pharmacological Insight into Etanercept and Pregabalin in Allodynia and Nociception: Behavioral Studies in a Murine Neuropathic Pain Model.
Brain Sci
November 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Neuropathic pain is challenging to treat, often resistant to current therapies, and associated with significant side effects. Pregabalin, an anticonvulsant that modulates calcium channels, is effective but can impair mental and motor functions, especially in older patients. To improve patient outcomes, reducing the doses of pregabalin and combining it with other drugs targeting different neuropathic pain mechanisms may be beneficial.
View Article and Find Full Text PDFFrom regional signal to alert in addictovigilance.
Therapie
October 2024
Inserm U 1058, Pathogenesis and Control of Chronic Infections (PCCI), centre d'addictovigilance, Montpellier University Hospital, 34000 Montpellier, France.
France has several monitoring systems that form the foundation of its health safety surveillance. This system is designed for the early detection of signals and their swift into an action system that enables timely, appropriate, and effective interventions to protect public health. These signals are considered alerts when sufficiently validated after an initial risk assessment and if they represent a potential threat to public health, necessitating an appropriate response.
View Article and Find Full Text PDFBrazilian Psychiatric Association guidelines for the treatment of Social Anxiety Disorder.
Braz J Psychiatry
November 2024
Mental Health Department, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Article Synopsis
- Social anxiety disorder (SAD) is a common yet often overlooked condition that can severely impact various aspects of a person's life, highlighting the need for tailored treatment guidelines, particularly in Brazil.
- A systematic review analyzed various treatment options for SAD, identifying selective serotonin reuptake inhibitors (SSRIs) as the preferred medication, with cognitive behavioral therapy (CBT) recognized as the top psychological intervention.
- The study emphasizes the importance of considering factors like access to treatments, adherence, response rates, and side effects in selecting the most effective SAD treatment for patients in Brazil.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!