AI Article Synopsis
- SARS-CoV-2 vaccines have been widely administered, leading to various side effects, including lymphadenopathy.
- A unique case involved a 41-year-old man who experienced swollen lymph nodes and fever after receiving his first dose of the mRNA-1273 vaccine, resulting in a diagnosis of Kikuchi disease.
- This case is notable as it is the first report showing SARS-CoV-2 expression in the lymph nodes of a patient diagnosed with Kikuchi disease post-vaccination.
Article Abstract
SARS-CoV-2 vaccines have been administered in many countries after the COVID-19 pandemic. Lymphadenopathy is a side effect of SARS-CoV-2 vaccine. We report a rare example of Kikuchi disease in the cervical lymph nodes after SARS-CoV-2 vaccination. A 41-year-old man complained of a swollen neck and fever 9 days after the first dose of SARS-CoV-2 mRNA-1273 vaccine. Computed tomography revealed enlarged cervical lymph nodes. Fine needle aspiration and resection were performed, and the clinicopathological diagnosis was consistent with Kikuchi disease. Histologically, the resected lymph nodes lost their polarity, and many histiocytes were aggregated with karyorrhectic nuclear debris and apoptosis. SARS-CoV-2 positive cells were small lymphocytes detected by immunohistochemistry. This is the first report that demonstrated SARS-CoV-2 expression in Kikuchi disease post-SARS-CoV-2 vaccination.
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| http://dx.doi.org/10.1177/10668969231212428 | DOI Listing |
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