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Infantile pyknocytosis, a neonatal hemolytic anemia with Heinz bodies: A cohort study.
Pediatr Blood Cancer
August 2024
Service d'Hématologie Biologique, CHRU Nancy, Nancy, France.
Infantile pyknocytosis (IP) is a rare, probably misestimated, cause of non-immune neonatal hemolytic anemia evolving in two phases: an initial phase with severe jaundice, followed by a second phase with hemolytic anemia, which may require neonatal intensive care. The diagnosis of IP is based on the transient presence on blood smear of hyperdense, contracted, and/or spiculated red blood cells (pyknocytes), associated with the spontaneous resolution of clinico-biological features and the exclusion of other causes. If the etiology remains undetermined, some contributing factors, such as oxidative stress, have been proposed.
View Article and Find Full Text PDFPyknocytosis, a rare form of neonatal haemolytic anaemia.
An Pediatr (Engl Ed)
December 2023
Unidad de Cuidados Especiales Neonatales, Servicio de Pediatría, Hospital de Braga EPE, Braga, Portugal.
Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin.
Biomed Hub
December 2020
Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Infantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest that transfusions might be avoidable in this condition by administering recombinant erythropoietin.
View Article and Find Full Text PDFInfantile Pyknocytosis in a Premature Dichorionic Diamniotic Twin.
J Pediatr Hematol Oncol
October 2021
Clinical Chemistry, Deventer Hospital, Deventer.
Infantile pyknocytosis is a rare and self-limiting cause of hemolytic anemia in neonates. It can result in severe anemia and hyperbilirubinemia. The pathogenesis is unknown: a genetic origin has been discussed; however, based on the current literature it is not clear which genetic mutations should be considered.
View Article and Find Full Text PDFInfantile Pyknocytosis: An Uncommon Cause of Newborn Hemolytic Anemia.
J Pediatr Hematol Oncol
May 2020
Infantile pyknocytosis is a rare cause of neonatal hemolytic anemia, which presents in the first few weeks of life. We report a classic case of infantile pyknocytosis that presented to our institution with rebound hyperbilirubinemia after receiving phototherapy. The infant was found to have a hemoglobin of 5.
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