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Impact of HPMCAS Grade on the Release of Weakly Basic Drugs from Amorphous Solid Dispersions.
Mol Pharm
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Oppositely charged species can form electrostatic interactions in aqueous solution, and these may lead to reduced solubility of the interacting components. Herein, insoluble complex formation between the lipophilic weakly basic drugs, cinnarizine or loratadine, and the enteric polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS), was studied and used to better understand drug and polymer release from their corresponding amorphous solid dispersions (ASDs). Surface area normalized release experiments were performed at various pH conditions for three different grades of HPMCAS, LF, MF and HF, as well as their ASDs.
View Article and Find Full Text PDFShedding Light on Falls: The Effect of Lighting Levels on Fall Risk in Long-Term Residential Care Facilities.
J Appl Gerontol
December 2024
School of Nursing, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
To compare lighting levels in care facilities with local recommendations and determine their cross-sectional association with fall rate, we recruited residents ( = 126) from 12 long-term care facilities (mean ± SD age 85.1 ± 7.9 years; 64.
View Article and Find Full Text PDFCulturally Tailored Messages and Trial Registry Enrollment: A Randomized Clinical Trial.
JAMA Netw Open
November 2024
The Annenberg School for Communication, University of Pennsylvania, Philadelphia.
Importance: Marginalized populations have lower levels of clinical trial representation than other populations. Tailoring recruitment materials and providing incentives may improve representation.
Objective: To determine whether culturally tailored video improves parents' decision to enroll (DTE) Black children in a research registry.
ω-Carboxyl terminated cellulose esters are effective crystallization inhibitors for challenging drugs.
J Pharm Sci
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Polymeric additives are widely used to delay drug crystallization from supersaturated solutions, which is critical for enhancing oral bioavailability by amorphous solid dispersion (ASD). The efficacy of these polymers relies on their capacity to inhibit nucleation and subsequent crystal growth. Drug nucleation is pivotal to crystallization; therefore, effective polymers are essential for suppressing nucleation from supersaturated solutions.
View Article and Find Full Text PDFDissolution mechanisms of amorphous solid dispersions: Role of polymer molecular weight and identification of a new failure mode.
J Pharm Sci
January 2025
Department of Industrial and Molecular Pharmaceutics, College of Pharmacy, Purdue University, West Lafayette, IN 47907, United States. Electronic address:
The mechanisms of drug release from amorphous solid dispersions (ASDs) are complex and not fully explored, making it difficult to optimize for in vivo performance. A recurring behavior has been the limit of congruency (LoC), a drug loading above which the ASD surface forms an amorphous drug-rich barrier in the presence of water, which hinders release, especially in non-sink conditions. Drug-polymer interactions and drug glass transition temperature were reported to affect the LoC.
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