Redefining stroke rehabilitation: Mobilizing the embodied goal-oriented brain.

Curr Opin Neurobiol

Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, the Netherlands.

Published: December 2023

Advancements in stroke rehabilitation remain limited and call for a reorientation. Based on recent results, this study proposes a network-centric perspective on stroke, positing that it not only causes localized deficits but also affects the brain's intricate network of networks, transiting it into a pathological state. Translating these system-level insights into interventions requires brain theory, and the Distributed Adaptive Control (DAC) theory offers such a framework. When applied in the rehabilitation gaming system, these principles demonstrate superior results over conventional methods. This impact stems from activating extensive brain networks, particularly the executive control network, focused motor learning, and maintaining excitatory-inhibitory balance, which is essential for neural repair and functional reorganization. The analysis stresses uniting preclinical and clinical research and placing the architecture of the embodied volitional brain at the centre of rehabilitation approaches.

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http://dx.doi.org/10.1016/j.conb.2023.102807DOI Listing

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