AI Article Synopsis
- Protein kinases play a crucial role in protein phosphorylation and are key players in signal transduction pathways in cells, particularly neurons.
- The study focuses on mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) as potential regulators of neurite outgrowth and synaptogenesis, using the selective inhibitor PF06260933.
- Results showed that inhibiting MAP4Ks led to shorter neurite lengths and reduced phosphorylation of specific proteins, suggesting their vital role in normal neuronal development and a link to psychiatric disorders when their activity is impaired.
Article Abstract
Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we considered mitogen-activated protein kinase kinase kinase kinases (MAP4Ks), related to as candidate regulators of neurite outgrowth and synaptogenesis, by examining the effects of a selective MAP4K inhibitor PF06260933. PF06260933 treatments of the cultured neurons reduced neurite lengths, not the number of synapses, and phosphorylation of GAP43 and JNK, relative to the control. These results suggest that MAP4Ks are physiologically involved in normal neuronal development and that the resultant impaired neurite outgrowth by diminished MAP4Ks' activity, is related to psychiatric disorders.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10656890 | PMC |
| http://dx.doi.org/10.1186/s13041-023-01066-2 | DOI Listing |
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