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http://dx.doi.org/10.1038/s41372-023-01826-x | DOI Listing |
Microorganisms
December 2024
Department of Diagnostic, Paediatric, Clinical and Surgical Science, University of Pavia, 27100 Pavia, Italy.
In solid organs post-transplant, bacterial infections can complicate the course of recovery with devastating consequences, such as graft loss and death. We provide an expert review on early post-liver transplant bacterial infections, with a focus on infections with multi-drug-resistant organism (MDRO) etiologies. Best practice recommendations are derived from a combination of available evidence and expert consensus.
View Article and Find Full Text PDFTher Adv Drug Saf
January 2025
College of Pharmacy, Jinan University, Guangzhou, Guangdong 511436, China.
Front Public Health
January 2025
Department of Medicine, Student Research Center, Iran University of Medical Sciences, Tehran, Iran.
Introduction: The self-medication of antibiotics is a global crisis, posing a significant challenge to healthcare systems worldwide. This study aimed to investigate the frequency of self-medication in the adult population and the factors influencing it.
Methods: This population-based cross-sectional study was conducted in Arak, a city in central Iran, from January 2019 to January 2020.
Int J Antimicrob Agents
December 2024
School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China. Electronic address:
Objectives: The research aimed to provide a worldwide evaluation of antimicrobial resistance (AMR), focusing specifically on AMR related to lower respiratory infections (LRI).
Methods: The data were derived from the Global Antimicrobial Resistance Burden 2021 (GARB 2021). Two counterfactuals were utilized to estimate the deaths attributable to AMR and the deaths associated with AMR.
J Infect Dis
December 2024
The National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Background: Current guidelines recommend combining a macrolide with a β-lactam antibiotic for the empirical treatment of moderate-to-high severity community-acquired pneumonia (CAP); however macrolide use is associated with potential adverse events and antimicrobial resistance.
Methods: We analysed electronic health data from 8,872 adults in Oxfordshire, UK, hospitalised with CAP between 01-January-2016 and 19-March-2024, who received either amoxicillin or co-amoxiclav as initial treatment. We examined the effects of adjunctive macrolides on 30-day all-cause mortality, time to hospital discharge, and changes in Sequential Organ Failure Assessment (SOFA) score, using inverse probability treatment weighting to address confounding by baseline severity.
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