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Analyzing the adverse events of NK-1 receptor antagonists: a pharmacovigilance study from the FAERS database.
Sci Rep
December 2024
Department of Pharmacy, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, 215153, China.
Background: NK-1 receptor antagonists (NK-1RAs) are proven to be successful in preventing chemotherapy-induced nausea and vomiting (CINV). The safety profile of NK-1RAs has not been systematically analyzed in the real world. This pharmacovigilance study investigated the differences in adverse events (AEs) between NK-1RAs.
View Article and Find Full Text PDFThe necessity of validity diagnostics when drawing causal inferences from observational data: lessons from a multi-database evaluation of the risk of non-infectious uveitis among patients exposed to Remicade.
BMC Med Res Methodol
December 2024
Janssen Research & Development LLC, Global Epidemiology Organization, Raritan, NJ, USA.
Background: Autoimmune disorders have primary manifestations such as joint pain and bowel inflammation but can also have secondary manifestations such as non-infectious uveitis (NIU). A regulatory health authority raised concerns after receiving spontaneous reports for NIU following exposure to Remicade, a biologic therapy with multiple indications for which alternative therapies are available. In assessment of this clinical question, we applied validity diagnostics to support observational data causal inferences.
View Article and Find Full Text PDFInfluence of the COVID-19 Pandemic on Influenza and SARS-CoV-2 Vaccination Willingness Among Dutch Nursing Home Health Care Workers.
J Am Med Dir Assoc
December 2024
Amsterdam UMC Location University of Amsterdam, Medical Microbiology and Infection Prevention, Amsterdam, the Netherlands; Amsterdam institute for Immunology and Infectious Diseases, Infectious Diseases, Amsterdam, the Netherlands.
Objectives: To explore the influenza and COVID-19 vaccination status among Dutch nursing home (NH) health care workers (HCWs), factors associated with vaccination including the influence of the pandemic, and the facilitators and barriers to vaccination willingness.
Design: An explanatory sequential mixed methods study.
Setting And Participants: HCWs providing direct care to residents in Dutch NHs.
Global burden of myocarditis from 1990 to 2021: findings from the Global Burden of Disease Study 2021.
BMC Cardiovasc Disord
December 2024
Department of Cardiology, The Second Hospital of Shanxi Medical University, 382 Wuyi Road, Taiyuan, Shanxi, 030001, China.
Background: Myocarditis is a major public health, social, and economic issue. Currently, few studies have provided comprehensive analyses of the global burden of myocarditis based on GBD (Global Burden Disease) 2021. We therefore analyzed long-term trends in the global burden of myocarditis from 1990 to 2021, described risk factors, examined the impact of COVID-19 (coronavirus infection disease 2019), and predicted future trends to inform health policy development and healthcare resource allocation.
View Article and Find Full Text PDFThe role of Real-World Evidence (RWE) concerns the entire drug lifecycle; despite widely recognised in the post-marketing, it is still debated in the pre-marketing, mainly as per the identification and analysis of target populations (TPs) for new drugs or indications. Through administrative healthcare databases, Research and Health Foundation (ReS), in collaboration with experts, develops algorithms to select and analyse TPs. As of March 2024, 85 TPs in 15 clinical areas have been analysed, of which oncology is the most represented.
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