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Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy. | LitMetric

Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy.

Int J Biol Macromol

Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu 59626, Republic of Korea. Electronic address:

Published: January 2024

AI Article Synopsis

  • * The characterization of these biomaterials was done using techniques like FE-SEM and FT-IR, and experiments showed that over 99% of CTP was released within 180 minutes at various pH and temperature conditions.
  • * Results demonstrated that the materials can release CTP continuously for up to 36 hours, suggesting they are promising for transdermal delivery in treating hypertension, with mechanisms of release differing between buffer solutions and artificial skin.

Article Abstract

Captopril (CTP) is an oral drug widely used to treat high blood pressure and congestive heart failure. In this study, CTP-incorporated biomaterials for antihypertensive therapy were synthesized from chitosan, carboxymethyl cellulose, and plasticizers. The physicochemical properties of the prepared biomaterials were characterized using FE-SEM, FT-IR analysis, and physical properties. CTP release experiments were carried out in buffer solutions at various pH values and temperatures. Results indicated that above 99.0 % of CTP was released within 180 min. Optimization of the experimental conditions for CTP release was analyzed by using response surface methodology (RSM). Results of CTP release through artificial skin indicated that CTP was continuously released above 95.0 % from the prepared biomaterials for 36.0 h. The CTP release mechanisms into a buffer and through artificial skin followed pseudo-Fickian diffusion mechanism and non-Fickian diffusion mechanisms, respectively. Moreover, angiotensin-converting enzyme (ACE) inhibition (related to cardiovascular disease) via the released CTP clearly reveals that the prepared biomaterials have a high potential as a transdermal drug delivery agent in antihypertensive therapy.

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Source
http://dx.doi.org/10.1016/j.ijbiomac.2023.128087DOI Listing

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