AI Article Synopsis
- The study aimed to investigate whether mitochondrial haplogroups influence the risk or severity of preeclampsia in pregnant women.
- After analyzing samples from 235 control and 78 preeclamptic pregnancies in Denmark, no significant links were found between haplogroups and preeclampsia.
- The researchers concluded that while common mitochondrial haplogroups do not appear to play a role, there may still be less common variations that warrant further investigation.
Article Abstract
Objective: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.
Methods: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.
Results: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.
Conclusion: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.
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| http://dx.doi.org/10.1016/j.preghy.2023.11.001 | DOI Listing |
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