AI Article Synopsis
- Oxytocin (OT) is a hormone that helps with important things like breastfeeding and connecting with others, and it might also affect how we eat.
- Research shows that OT affects parts of the brain that control eating, and giving OT to rats made them eat less and lose weight.
- OT could help people with eating disorders by reducing hunger or, in some cases like anorexia, even making them want to eat more, but more studies are needed to understand how to use it effectively.
Article Abstract
Background: The neuropeptide oxytocin (OT) is crucial in several conditions, such as lactation, parturition, mother-infant interaction, and psychosocial function. Moreover, OT may be involved in the regulation of eating behaviors.
Methods: This review briefly summarizes data concerning the role of OT in eating behaviors. Appropriate keywords and medical subject headings were identified and searched for in PubMed/MEDLINE. References of original articles and reviews were screened, examined, and selected.
Results: Hypothalamic OT-secreting neurons project to different cerebral areas controlling eating behaviors, such as the amygdala, area postrema, nucleus of the solitary tract, and dorsal motor nucleus of the vagus nerve. Intracerebral/ventricular OT administration decreases food intake and body weight in wild and genetically obese rats. OT may alter food intake and the quality of meals, especially carbohydrates and sweets, in humans.
Discussion: OT may play a role in the pathophysiology of eating disorders with potential therapeutic perspectives. In obese patients and those with certain eating disorders, such as bulimia nervosa or binge/compulsive eating, OT may reduce appetite and caloric consumption. Conversely, OT administered to patients with anorexia nervosa may paradoxically stimulate appetite, possibly by lowering anxiety which usually complicates the management of these patients. Nevertheless, OT administration (e.g., intranasal route) is not always associated with clinical benefit, probably because intranasally administered OT fails to achieve therapeutic intracerebral levels of the hormone.
Conclusion: OT administration could play a therapeutic role in managing eating disorders and disordered eating. However, specific studies are needed to clarify this issue with regard to dose-finding and route and administration time.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10847364 | PMC |
| http://dx.doi.org/10.1007/s42000-023-00505-y | DOI Listing |
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