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Diuretics for preventing and treating acute kidney injury.
Cochrane Database Syst Rev
January 2025
Department of Psychiatry, Soseikai General Hospital, Kyoto, Japan.
Background: Acute kidney injury (AKI) is a well-known complication of critical illnesses, significantly affecting morbidity and the risk of death. Diuretics are widely used to ameliorate excess fluid accumulation and oliguria associated with AKI. Their popularity stems from their ability to reduce the energy demands of renal tubular cells by inhibiting transporters and flushing out intratubular casts.
View Article and Find Full Text PDFRenal Histopathological Changes in Children With Congenital Ureteropelvic Junction Obstruction.
Clin Pediatr (Phila)
February 2025
Department of Pediatric Surgery, St. John's Medical College Hospital, Bangalore, Karnataka, India.
Renal histologic changes in congenital ureteropelvic junction obstruction (UPJO), although well documented, are sparsely studied in children. This study aims to establish a histological grading depending on the glomerular and tubulo-interstitial changes in hydronephrotic kidneys and determine correlation with age at surgery and impact on function post-pyeloplasty. A renal cortical wedge biopsy was obtained after pyeloplasty and histological changes were graded from 1 to 4.
View Article and Find Full Text PDFUtilization of cardiopulmonary bypass at radical nephrectomy for renal cell carcinoma with tumour thrombus.
BJUI Compass
January 2025
Department of Urology, Feinberg School of Medicine Northwestern University Chicago Illinois USA.
Objectives: The objective of this study is to evaluate preoperative factors associated with cardiopulmonary bypass (CPB) utilization and outcomes for patients with renal cell carcinoma (RCC) and tumour thrombus (TT). Radical nephrectomy with thrombectomy is a standard treatment for patients with RCC and associated TT. Morbidity and mortality rates tend to correlate with aggressiveness of tumour and TT level.
View Article and Find Full Text PDFPan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB.
Immunotargets Ther
January 2025
Institute of Integration of Traditional Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, People's Republic of China.
Introduction: Cancer is a widespread epidemic that affects millions of individuals across the world. Identifying novel cancer targets is crucial to developing more effective cancer treatments. Platelet-derived growth factor-B (PDGFB) plays a critical role in various tumor processes, including angiogenesis and lymphatic metastasis.
View Article and Find Full Text PDFResection and Reconstruction of the Inferior Vena Cava Using a Tunneled Peritoneal Graft for Renal Tumor With Thrombus: Venous Compensation via the Azygos Vein Following Early Graft Occlusion.
Cureus
December 2024
Surgery, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma De Nuevo León, Monterrey, MEX.
Inferior vena cava (IVC) invasion by tumor thrombus poses a significant surgical challenge, often requiring vascular reconstruction. Standard methods, including prosthetic and autologous vein grafts, have limitations such as infection risks, anticoagulation demands, and increased costs. We present the case of a 66-year-old male with a right renal tumor (T3bN0M0, Neves Zincke II) and gross hematuria, who underwent radical nephrectomy with open thrombectomy.
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