AI Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation leading to joint damage, with treatment aimed at reducing inflammation.
- Traditional medications may have non-specific effects on cell metabolism, prompting interest in specialized pro-resolving mediators (SPMs), which help resolve inflammation and restore tissue health.
- SPMs are derived from omega-3 fatty acids and their production may be disrupted in RA, highlighting their potential as protective and healing agents in managing the condition.
Article Abstract
Rheumatoid arthritis (RA) is classified as a persistent inflammatory autoimmune disorder leading to the subsequent erosion of articular cartilage and bone tissue originating from the synovium. The fundamental objective of therapeutic interventions in RA has been the suppression of inflammation. Nevertheless, conventional medicines that lack target specificity may exhibit unpredictable effects on cell metabolism. In recent times, there has been evidence suggesting that specialized pro-resolving mediators (SPMs), which are lipid metabolites, have a role in facilitating the resolution of inflammation and the reestablishment of tissue homeostasis. SPMs are synthesized by immune cells through the enzymatic conversion of omega-3 fatty acids. In the context of RA, there is a possibility of dysregulation in the production of these SPMs. In this review, we delve into the present comprehension of the endogenous functions of SPMs in RA as lipids that exhibit pro-resolutive, protective, and immunoresolvent properties.
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| http://dx.doi.org/10.1016/j.prostaglandins.2023.106798 | DOI Listing |
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