AI Article Synopsis
- * Its ability to change shape from yeast to filamentous form is linked to its transition from harmless to pathogenic, which is key to its virulence.
- * The review highlights the importance of these shape changes in how C. albicans grows in the gut and emphasizes the transcription factors that regulate these transformations.
Article Abstract
Candida albicans is a pathobiont in humans that forms part of the mycobiota in healthy individuals and can cause different pathologies upon alterations of the host defenses. The mammalian gut is clinically relevant as this niche is the most common pool for bloodstream-derived infections. The ability of C. albicans to switch from yeast to hypha has been related to the commensal-to-pathogen transition and is, therefore, considered relevant in virulence. Recently, filaments have been implicated in the humoral response in the gut. C. albicans exhibits other morphologies that play different roles in pathogenicity and commensalism. This review focuses on the role of these morphological transitions in C. albicans proliferation and its establishment as a commensal in the mammalian gut, paying special attention to the transcription factors involved in their regulation.
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| http://dx.doi.org/10.1016/j.micinf.2023.105253 | DOI Listing |
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