Methods: A cross-sectional analysis was conducted on a convenience sample of 138 adults with SCI, who completed a survey regarding knowledge and awareness of post-SCI bone health as part of a larger study. Self-reported demographic information and assessments of bone health knowledge were analyzed.
Results: Approximately 20% ( = 28) of participants had never heard of bone mineral density (BMD), 25% ( = 34) only vaguely remembered that BMD was mentioned during their hospitalization/rehabilitation after SCI, 36% ( = 50) clearly remembered that BMD was mentioned during their hospitalization/rehabilitation, and 17% ( = 24) reported having an individual or group education session on causes and management of low BMD during rehabilitation. Only 30% ( = 42) of participants believed they had adequate knowledge on the subject, while 70% ( = 96) believed their knowledge was inadequate or were unsure. Most participants (73%, n = 101) reported being concerned about the risks of low BMD after SCI and were interested in learning more about prevention (76%, n = 105) and treatment options (78%, n = 108).
Conclusions: While results suggest that most participants received some information regarding bone health in post-SCI care, over 70% of participants reported wanting more information about bone loss prevention and treatment, indicating bone health education is a patient priority in this population.
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http://dx.doi.org/10.1080/10790268.2023.2254445 | DOI Listing |
J Pediatr Adolesc Gynecol
December 2024
Amy Sass, children's hospital of Colorado, aurora Colorado. Electronic address:
The objective of this document is to guide the screening, diagnosis, and management of Relative Energy Deficiency in Sport (REDs) in Adolescent/Young Adult (AYA) athletes to treat symptoms and reduce long-term sequelae with a focus on gynecologic aspects of the disorder. REDs is a more comprehensive term for the condition previously known as the Female Athlete Triad. An overview of the clinical presentation, evaluation, and management of the reproductive health aspects of REDs for female athletes is provided.
View Article and Find Full Text PDFEur J Med Genet
December 2024
Rare Diseases and Medical Genetics Unit, Bambino Gesù Children's Hospital, IRCSS, Rome, Italy.
O'Donnell-Luria-Rodan (ODLURO) syndrome is an autosomal dominant neurodevelopmental disorder mainly characterized by global development delay/intellectual disability, white matter abnormalities, and behavioral manifestations. It is caused by pathogenic variants in the KMT2E gene. Here we report seven new patients with loss-of-function KMT2E variants, six harboring frameshift/nonsense changes, and one with a 7q22.
View Article and Find Full Text PDFMol Cell
December 2024
Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. Electronic address:
The efficacy of antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation. Despite this, it is unclear how genetic diversification mechanisms evolved alongside codon optimality and affect antibody expression. Here, we analyze germline immunoglobulin (IG) genes, natural V(D)J repertoires, serum IgG, and monoclonal antibody (mAb) expression through the lens of codon optimality.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
December 2024
Oral Technology, Dental School, University Hospital Bonn, Bonn, Germany. Electronic address:
Biomater Adv
December 2024
Department of Orthopaedic Surgery, UC Davis Health, Sacramento, CA, USA; Department of Biomedical Engineering, University of California, Davis, CA, USA. Electronic address:
Osteosarcoma (OS), the most common form of primary bone cancer in young adults, has had no improvements in clinical outcomes in 50 years. This highlights a critical need to advance mechanistic understanding of OS to further therapeutic discovery, which will only be possible with accurate models of the disease. Compared to traditional monolayer studies and preclinical models, in vitro models that better replicate the three-dimensional (3D) bone marrow microenvironment will facilitate methodical investigations of the events and factors that drive OS progression.
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