Objective: Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women.
Methods: Placental samples were collected from AGA ( = 40) and SAG ( = 40) neonates. The methylation of IGF-axis genes promoter was analyzed using MS-PCR.
Results: , , and genes promoter methylation was 2.5, 1.5, 5, and 7.5% lower in SGA compared to AGA, respectively. Co-methylation of IGF-axis genes promoter was 40% and 20% in AGA and SGA, respectively. IGF-axis gene promoter methylation significantly ( < 0.05) influenced the levels of IGFBP3 protein, birth weight, mitotic index, gestational weeks, and and gene expression.
Conclusion: IGF-axis genes methylation was lower in SGA than in AGA, and the methylation significantly influenced the IGF-axis components.
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