AI Article Synopsis
- - The study investigated the effects of empagliflozin, a diabetes medication, on cardiac function and biomarkers in patients with type 2 diabetes and coronary artery disease over 26 weeks, comparing it to a placebo.
- - Results showed that empagliflozin significantly reduced the levels of high-sensitivity cardiac troponin-I (hs-cTnI), suggesting improved heart muscle function, while also showing modest changes in lipid profiles like increased HDL cholesterol.
- - The findings indicate that empagliflozin potentially benefits cardiac health in diabetic patients, although its effects on cholesterol levels were less pronounced.
Article Abstract
Background: Empagliflozin is a sodium glucose cotransporter-2 (SGLT2) inhibitor that has been suggested to improve cardiac function and vascular recovery. The risk of coronary artery diseases is much higher in diabetic patients and is associated with greater morbidity and mortality. High-sensitivity cardiac troponin-I (hs-cTnI) is an important prognostic biomarker in cardiac diseases. Therefore, this study aimed to investigate the effect of empagliflozin compared to placebo on changes in hs-cTnI and lipid profile after 26 weeks of treatment.
Methods: This was an ancillary study in a randomized trial of patients with concomitant type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) (The EMPA-CARD study). Patients who were already on standard anti-diabetic/anti-ischemic medications were randomized to receive either placebo or empagliflozin 10 mg/daily. Serum hs-cTnI and lipid profile were measured at baseline and after 26 weeks.
Results: Of the 95 randomized patients, hs-cTnI and lipid profile were measured for a total of 77 patients. No significant difference was observed regarding the baseline characteristics between the two arms. Compared to placebo, empagliflozin significantly reduced hs-cTnI after 26 weeks (mean difference (MD) of -13.242, 95%CI: -14.151 to -12.333, < 0.001). In the empagliflozin group, non-significant reductions in total cholesterol, LDL-C, and triglyceride have resulted; however, there was an increase in HDL-C level (MD = 2.40,95%CI:0.16-4.60, < 0.04).
Conclusion: Empagliflozin compared to placebo was superior in reducing circulating hs-cTnI that may indicate improvements in cardiomyocytes function in patients with T2DM and CAD. Moreover, empagliflozin had a modest impact on the serum lipid profile biomarkers.
Trial Registration: The original EMPA-CARD study has been registered in Iranian Registry of Clinical Trials. www.IRCT.ir, Identifier: IRCT20190412043247N2. Registration Date: 6/13/2020. Registration timing: prospective.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638116 | PMC |
| http://dx.doi.org/10.1007/s40200-023-01305-2 | DOI Listing |
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