Aim: To determine the correlation of iron deficiency anaemia (IDA) in patients diagnosed with Laryngo Pharyngeal Reflux Disease (LPRD).
Materials And Methods: 100 patients who presented to the OPD, diagnosed to have LPRD based on the Reflux Symptom Index (score > 13) and the Reflux Findings Score (score > 9), were subjected to a Complete Blood count and Peripheral smear examination to look for indices suggestive of an Iron deficiency state or anaemia.
Results: 58% (58) of the patients included in the study had Hb less than 11.5 g/dl with an average Hb of 11 g/dl. 93% (93) had PCV < 40%, and 94% (94) had elevated RDW (> 14.5%). 53% of the patients included had low MCV, MCH, and MCHC. 53% of the patients showed features of microcytic hypochromic RBCs on the peripheral smear. Elevated RDW can be used as an indicator of an iron-deficient state in populations with a high prevalence of IDA, like India.
Conclusion: The study shows a strong correlation between LPRD and an Iron deficient state. However, whether iron deficiency is the cause or effect of LPRD needs to be determined further. Further research in this area could shed light on the pathophysiology of LPRD and have implications for its treatment.
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http://dx.doi.org/10.1007/s12070-023-03925-9 | DOI Listing |
BMC Nutr
December 2024
Department of Food Science and Postharvest Technology, Faculty of Agriculture and Environment, Gulu University, P.O. Box 166, Gulu, Uganda.
Background: Globally, iron deficiency anaemia is a widespread public health problem affecting vulnerable populations including adolescents. However, over the years, the Uganda Demographic Health Surveys mostly report the status of anaemia for women of reproductive age (15-49 years) and children up to 5 years, leaving out the focus on adolescents. Moreover, high prevalence of anaemia among children below five years could suggest that anaemia still persists at adolescence.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
December 2024
Department of Public Health, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia.
Background: Despite the integration of iron supplementation into routine antenatal care programs as a nutritional intervention to prevent anemia in pregnant women, the use of this supplement for the recommended duration remains low in sub-Saharan Africa (SSA). Evidence on maternal compliance with iron supplementation at the SSA level is lacking and most of the previous studies have been limited to specific geographic areas. Therefore, the current study used large population survey data from 35 SSA countries to estimate the pooled prevalence of non-adherence and its determinants.
View Article and Find Full Text PDFFerredoxin 1 and 2 (FDX1/2) constitute an evolutionarily conserved FDX family of iron-sulfur cluster (ISC) containing proteins. FDX1/2 are cognate substrates of ferredoxin reductase (FDXR) and serve as conduits for electron transfer from NADPH to a set of proteins involved in biogenesis of steroids, hemes, ISC and lipoylated proteins. Recently, we showed that Fdx1 is essential for embryonic development and lipid homeostasis.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Internal Medicine, Istanbul Medeniyet University, Fahrettin Kerim Gokay Street, Kadikoy, 34722, Istanbul, Turkey.
Iron deficiency anemia (IDA) is prevalent among women of reproductive age. Treatment aims to replenish iron stores and normalize hemoglobin levels, with oral iron therapy being the preferred route in most cases. This study aimed to compare the efficacy and side effects of three common oral treatment regimens in premenopausal women with IDA.
View Article and Find Full Text PDFVet Sci
November 2024
Department of Small Animal Internal Medicine, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 260, CH-8057 Zürich, Switzerland.
Dyserythropoietic anemia and myopathy syndrome (DAMS) with neonatal losses was recently characterized as an autosomal recessive disorder caused by an frameshift variant in English Springer Spaniels (ESSPs). The frequency and dissemination of the mutation remained unknown. The EHBP1L1 protein is essential for muscle function, and the Rab8/10-EHBP1L1-Bin1-dynamin axis participates in nuclear polarization during the enucleation of erythroblasts.
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