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Treatment of pembrolizumab-induced bullous pemphigoid with dupilumab: A case report and review of the literature.
Int J Dermatol
December 2024
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Brain Freeze: Pembrolizumab-Induced Autoimmune Encephalitis in Triple-Negative Breast Cancer.
Cureus
November 2024
Hematology and Oncology, Einstein Medical Center Montgomery, East Norriton, USA.
This case report presents the first known instance of pembrolizumab-induced autoimmune encephalitis in a 41-year-old female patient with stage IIIc triple-negative breast cancer. The patient developed expressive aphasia three days after starting pembrolizumab in combination with chemotherapy, prompting comprehensive evaluations that ruled out infectious or metastatic causes. A diagnosis of pembrolizumab-associated autoimmune encephalitis was established following a lumbar puncture and MRI.
View Article and Find Full Text PDFPembrolizumab-induced acquired lipodystrophy: a case report and review of the literature.
Melanoma Res
December 2024
Department of Medicine, School of Medicine, University of Utah.
Acquired generalized lipodystrophy (AGL) is a rare complication of immune checkpoint inhibitors (ICIs) and is associated with immune-mediated loss of adipose tissue, peripheral resistance to insulin, and serious metabolic complications. Here we report a new case of ICI-induced AGL and provide an updated literature review of published cases. We report a 39-year-old female patient treated with adjuvant pembrolizumab for stage IIIC nevoid melanoma with ICI-induced AGL.
View Article and Find Full Text PDFPembrolizumab-induced Stevens-Johnson syndrome-like reaction: An atypical clinical presentation.
JAAD Case Rep
December 2024
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.
Article Synopsis
- * She was diagnosed with hyperglycemia and ketosis, treated for diabetic ketoacidosis (DKA) with insulin, and later transitioned to an insulin regimen after discharge.
- * The case is significant for recognizing immune checkpoint inhibitor-induced diabetes mellitus (ICI-DM) as a potential side effect of immunotherapy, leading to the discontinuation of her cancer treatment and planning for surgery.
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