Walter Bauer was instrumental in the development of rheumatology as a medical subspecialty, promoting careful clinical observation and description and bringing basic scientists and clinicians together to study the "anatomy, chemical composition, and metabolism of connective tissue" in the laboratory. Marian Wilkins Ropes was a pioneering woman in medicine: the first female medical resident at the Massachusetts General Hospital, the first woman appointed as an assistant professor of clinical medicine at Harvard Medical School, the first woman elected to membership in the American Society of Clinical Investigation, and the first woman elected president of the American Rheumatism Association.
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| http://dx.doi.org/10.1016/j.rdc.2023.09.001 | DOI Listing |
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Solid state NMR and computational studies on cyclopentadienyl lithium.
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Institute of Organic Chemistry II, Department Chemistry and Pharmacy, University of Erlangen-Nürnberg, Nikolaus-Fiebiger-Strasse 10, 91058, Erlangen, Germany.
Lithiumcyclopentadienide, previously identified to be an endless polymer in the ligand-free solid state, was investigated by C- and Li-CP/MAS NMR spectra, and by B3LYP-GIAO theoretical calculations. By spectra simulation, the axially symmetric C-shift tensor components were identified to be δ = δ = 151.5 ppm, δ = 15.
View Article and Find Full Text PDFThe straightforward and efficient synthesis of complex aza- and carbobicyclic compounds, which are of importance for medicinal chemistry, is a challenge for modern chemical methodology. An unprecedented metal-free six-step domino reaction of aldehydes with malononitrile was presented in our previous study to provide, in a single operation, these bicyclic nitrogen-containing molecules. Presented here is a deeper investigation of this atom-economical domino process by extending the scope of aldehydes, performing post-modifications of domino products, applying bifunctional organocatalysts and comprehensive NMR studies of selected domino products.
View Article and Find Full Text PDFProduction of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
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Department of Pharmacy, Universidade Federal of Minas Gerais, Belo Horizonte, Brazil.
Recent studies demonstrate that cardiac glycosides, known to inhibit Na/K-ATPase in humans, have increased susceptibility to cancer cells that can be used in tumor therapy. One of the most promising candidates identified so far is glucoevatromonoside, which can be isolated from the endangered species ssp. .
View Article and Find Full Text PDFGeneration of Complex Azabicycles and Carbobicycles from Two Simple Compounds in a Single Operation through a Metal-Free Six-Step Domino Reaction.
Chemistry
April 2016
Institute of Organic Chemistry and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestrasse 42, 91054, Erlangen, Germany.
Aza- and carbobicyclic compounds possess favorable pharmaceutical properties, but they are difficult to access. Herein, we demonstrate an unprecedented organocatalytic two component six-step chemodivergent domino reaction, which provides a straightforward, sustainable and atom economical route to difficult-to-access complex bicyclic architectures: azabicycles and carbobicycles, whose ratios can be controlled by the applied electrophiles and catalysts. Detailed NMR and X-ray studies on the structures and relative stereochemistry of selected compounds are presented.
View Article and Find Full Text PDFSynthesis and Atropisomerism of Cascaded Tetraphenylporphyrin-[60]Fullerene Hybrids.
Chemistry
August 2015
Department of Chemistry and Pharmacy & Interdisciplinary Center of Molecular Materials (ICMM), Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestrasse 42, 91054 Erlangen (Germany), Fax: (+49) 9131-852-6864.
Flexible, linked dendritic tetraphenylporphyrin (TPP)-fullerene hybrids were synthesized. They were designed to gain insight into and mimic the primary events in the natural photosynthetic reaction center. These multiporphyrin moieties are based on a light-harvesting concept.
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