AI Article Synopsis
- Macacine alphaherpesvirus 1, or herpes B virus, is a virus found in macaque monkeys that can infect humans and cause serious illness with high mortality risks.
- A unique case of this virus reactivating after 54 years resulted in severe meningoencephalitis, highlighting the need for antiviral preventive measures in survivors of central nervous system infections.
- DNA sequencing of the virus from the patient's cerebrospinal fluid revealed it had significant genetic differences compared to other known strains, suggesting the need for more research on various BVs in monkeys.
Article Abstract
Macacine alphaherpesvirus 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54 years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient's cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793070 | PMC |
| http://dx.doi.org/10.4269/ajtmh.23-0253 | DOI Listing |
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