AI Article Synopsis

  • Younger breast cancer survivors often experience significant symptoms related to chemotherapy and the menopausal transition, impacting their quality of life (QOL).
  • This study focused on premenopausal women under 50 diagnosed with stage I to III breast cancer, evaluating factors linked to chemotherapy-related amenorrhea (CRA) and its long-term effects on QOL over four years.
  • The findings showed that a significant percentage of participants experienced persistent CRA, with older age being a predictor, highlighting the need for better management of treatment-related symptoms in younger survivors.

Article Abstract

Importance: Younger survivors of breast cancer frequently report more treatment-related symptoms, mostly related to the menopausal transition.

Objective: To assess factors associated with chemotherapy-related amenorrhea (CRA) and to evaluate its association with long-term quality of life (QOL).

Design, Setting, And Participants: The prospective, longitudinal Cancer Toxicities Study, a multicenter French cohort study, includes women with a diagnosis of stage I to III breast cancer and collects data approximately yearly after diagnosis. The current study reports outcomes up to 4 years after diagnosis for participants enrolled from 2012 to 2017. Participants included premenopausal women younger than 50 years treated with chemotherapy and not receiving adjuvant ovarian function suppression. Data analysis was performed from September 2021 to June 2023.

Exposures: Clinical, socioeconomic, tumor, and treatment characteristics assessed at diagnosis (for the analysis of factors associated with CRA) and persistent CRA (for the QOL analysis).

Main Outcomes And Measures: The main outcome of interest was CRA at year 1 (Y1), year 2 (Y2), and year 4 (Y4) after diagnosis. Generalized estimating equations assessed associations of exposure variables with CRA. In the QOL analysis, QOL at Y4 (assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires C30 and BR23) was the outcome of interest. Multivariable random-effect mixed models assessed the association of persistent CRA (ie, never recovering menses after treatment) with QOL.

Results: Among 1636 women, the mean (SD) age at diagnosis was 42.2 (5.6) years. Overall, 1242 of 1497 women (83.0%) reported CRA at Y1, 959 of 1323 women (72.5%) reported it at Y2, and 599 of 906 women (66.1%) reported it at Y4. Older age vs 18 to 34 years (adjusted odds ratio [OR] for 35 to 39 years, 1.84 [95% CI, 1.32 to 2.56]; adjusted OR for 40 to 44 years, 5.90 [95% CI, 4.23 to 8.24]; and adjusted OR for ≥45 years, 21.29 [95% CI, 14.34 to 31.61]) and receipt of adjuvant tamoxifen (adjusted OR, 1.97 [95% CI, 1.53 to 2.53]) were associated with higher likelihood of CRA. In the QOL analysis, 416 of 729 women (57.1%) had persistent CRA. However, late menses recovery among women aged 18 to 34 years with no menses at Y2 were reported by 11 of 21 women (52.4%) between Y2 and Y4. Persistent CRA was associated with worse insomnia (mean difference vs recovery at any time, 9.9 points [95% CI, 3.2 to 16.5 points]; P = .004), systemic therapy-related adverse effects (mean difference, 3.0 points [95% CI, 0.2 to 5.8 points]; P = .04), and sexual functioning (mean difference, -9.2 points [95% CI, -14.3 to -4.1 points]; P < .001) at Y4.

Conclusions And Relevance: In this cohort study of premenopausal women with breast cancer, persistent CRA was common, although some women recovered menses late, and was associated with worse long-term QOL. This study can help inform risk communication, personalized counseling, and early supportive care referrals for such patients.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654794PMC
http://dx.doi.org/10.1001/jamanetworkopen.2023.43910DOI Listing

Publication Analysis

Top Keywords

persistent cra
16
quality life
12
breast cancer
12
cra qol
12
points [95%
12
women
10
cra
10
chemotherapy-related amenorrhea
8
premenopausal women
8
factors associated
8

Similar Publications

Genetic diversity, drug resistance, and biofilm formation in Klebsiella pneumoniae associated with nosocomial infection in Pelotas, RS, Brazil.

Braz J Microbiol

December 2024

Programa de Pós-Graduação Em Biotecnologia (PPGB), Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil.

Article Synopsis
  • - The study investigates antibiotic resistance and biofilm formation in Klebsiella pneumoniae strains from a university hospital in Pelotas, Brazil, highlighting the strains' persistence in hospital settings.
  • - Out of 28 K. pneumoniae isolates, a significant majority (96.42%) strongly formed biofilms, with 64.29% classified as multidrug-resistant (MDR), revealing a concerning level of antibiotic resistance.
  • - Genetic analysis showed 18 unique clones, indicating that the same strains circulated in different samples over two years, underscoring the need for improved control measures and disinfection protocols in hospital environments.
View Article and Find Full Text PDF

Colorectal adenomas (CRAs) represent precancerous lesions that precede the development of colorectal cancer (CRC). Regular monitoring of CRAs can hinder the progression into carcinoma. To explore the utility of tissue DNA and circulating cell-free DNA (cfDNA) in early diagnosis of CRC, we retrospectively sequenced paired tissue and plasma samples from 85 patients with conventional CRAs.

View Article and Find Full Text PDF

Chronic Rheumatologic Disease in Chikungunya Virus Fever: Results from a Cohort Study Conducted in Piedecuesta, Colombia.

Trop Med Infect Dis

October 2024

Centro de Atención y Diagnóstico de Enfermedades Infecciosas (CDI), Fundación INFOVIDA, Cra. 37 No. 51-126, Bucaramanga 680003, Colombia.

Article Synopsis
  • The study examined the long-term effects of chikungunya virus (CHIKV) infection, focusing on the incidence of post-chikungunya chronic rheumatism (pCHIK-CR) and its effects on quality of life (QoL) and chronic fatigue seven years after an outbreak in Piedecuesta, Colombia.
  • Among 78 adults evaluated, 14.1% were found to have pCHIK-CR, 41.0% had non-inflammatory pain, and 44.9% had no rheumatic disease, with those suffering from pCHIK-CR showing the worst QoL and highest levels of chronic fatigue.
  • The findings indicate that roughly one in seven individuals with CHIKV infection
View Article and Find Full Text PDF

Versatile injector for inline renewable solid-phase extraction: Application to cyclodextrin-based bioaccessibility assessment in environmental solids.

Anal Chim Acta

November 2024

University of Natural Resources and Life Sciences, Vienna, Department of Chemistry, Institute of Analytical Chemistry, Muthgasse 18, 1190, Wien, Austria. Electronic address:

Background: Solid phase extraction (SPE) is a standard sample preparation technique in HPLC workflows. Inline cartridges are high-performance alternatives to manual or robotic systems but at long term, they suffer from irreversible sorption of matrix components and sorbent compaction. Bead injection (BI) is a niche fluidic technique that allows renewing a sorbent bed through the manipulation of its suspension.

View Article and Find Full Text PDF

Background And Aims: INTERASPIRE is an international study of coronary heart disease (CHD) patients, designed to measure if guideline standards for secondary prevention and cardiac rehabilitation are being achieved in a timely manner.

Methods: Between 2020 and 2023, adults hospitalized in the preceding 6-24 months with incident or recurrent CHD were sampled in 14 countries from all 6 World Health Organization regions and invited for a standardized interview and examination. Direct age and sex standardization was used for country-level prevalence estimation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: