Aging can compromise decision-making and learning, potentially due to reduced exploratory behaviors crucial for novel problem-solving. We posit that invigorating exploration could mitigate these declines. Supporting this hypothesis, we found that older mice mirrored human aging, displaying less exploration and learning during decision-making, but optogenetic stimulation of their posterior parietal cortex boosted initial exploration, subsequently improving learning. Thus, enhancing exploration-driven learning could be a key to countering cognitive aging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642975 | PMC |
| http://dx.doi.org/10.1101/2023.10.21.563408 | DOI Listing |
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