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Hepatoprotective effects of Niudali () root aqueous extracts against tetrachloromethane-induced acute liver injury and inflammation. | LitMetric

AI Article Synopsis

  • Niudali, a plant common in southeastern China, has been shown to contain root extracts with various biological activities, especially its potential protective effects against liver damage, though this area hasn't been thoroughly researched.
  • The study explored two types of aqueous extracts from Niudali root and identified an alkaloid called hypaphorine, testing their effects on liver injury in mice induced by carbon tetrachloride.
  • Results indicated that these extracts and hypaphorine significantly reduced liver damage and oxidative stress, improved liver function markers, and modulated inflammatory responses, suggesting Niudali could be beneficial as a dietary approach to support liver health.

Article Abstract

Niudali () is commonly grown in southeastern regions of China and consumed as a food ingredient. Although Niudali root extracts showed various biological activities, the hepatoprotective effects of Niudali root phytochemicals are not fully studied. Herein, we prepared two Niudali root aqueous extracts, namely, c and Niudali polysaccharides-enriched extract (NPE), and identified an alkaloid, (hypaphorine) in NEW. The hepatoprotective effects of NWE, NPE, and hypaphorine were evaluated in an acute liver injury model induced by carbon tetrachloride (CCl) in mice. Pathohistological examination and blood chemistry assays showed that treatment of NWE, NPE, and hypaphorine alleviated CCl-induced liver damage by lowering the liver injury score (by 75.51%, 80.01%, and 41.22%) and serum aspartate and alanine transaminases level (by 63.24%, 85.22%, and 49.74% and by 78.73%, 80.08%, and 81.70%), respectively. NWE, NPE, and hypaphorine also reduced CCl-induced hepatic oxidative stresses in the liver tissue by decreasing the levels of malondialdehyde (by 40.00%, 51.25%, and 28.75%) and reactive oxygen species (by 30.22%, 36.14%, and 33.54%) while increasing the levels of antioxidant enzymes including superoxide dismutase (by 21.36%, 21.64%, and 8.90%), catalase (by 22.13%, 33.33%, and 5.39%), and glutathione (by 84.87%, 90.65%, and 80.53%), respectively. Mechanistic assays showed that NWE, NPE, and hypaphorine alleviated liver damage by mediating inflammatory biomarkers (e.g., pro-inflammatory cytokines) via the signaling pathways of mitogen-activated protein kinases and nuclear factor-κB. Findings from our study extend the understanding of Niudali's hepatoprotective effects, which is useful for its development as a dietary intervention for liver inflammation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630805PMC
http://dx.doi.org/10.1002/fsn3.3626DOI Listing

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