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Transforming Alzheimer's Treatment: Unveiling New Potential with Drug Repurposing Strategies.
Curr Med Chem
January 2025
School of Medicine and Pharmacy, Duy Tan University, Da NangVietnam, Institute of Research and Development, Duy Tan University, Da Nang Vietnam.
Alzheimer's disease (AD) remains a significant challenge in neurology, marked by progressive cognitive decline and neurodegeneration. Despite extensive research efforts, effective treatments are still lacking. Traditional drug discovery is often slow and costly, frequently resulting in limited success.
View Article and Find Full Text PDFProspective Applications of Artificial Intelligence In Fetal Medicine: A Scoping Review of Recent Updates.
Int J Gen Med
January 2025
Department of Pediatrics, College of Medicine, Arab Gulf University, Al Manama, Bahrain.
Introduction: With the incorporation of artificial intelligence (AI), significant advancements have occurred in the field of fetal medicine, holding the potential to transform prenatal care and diagnostics, promising to revolutionize prenatal care and diagnostics. This scoping review aims to explore the recent updates in the prospective application of AI in fetal medicine, evaluating its current uses, potential benefits, and limitations.
Methods: Compiling literature concerning the utilization of AI in fetal medicine does not appear to modify the subject or provide an exhaustive exploration of electronic databases.
Nourishing Change in Houston, Texas: Exploring Grocery Shopping Behaviors and Fruit and Vegetable Consumption Among Low-Income Families in the Brighter Bites Program.
Public Health Nutr
January 2025
Department of Epidemiology, Human Genetics, and Environmental Science, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030. USA.
Objective: We qualitatively examine the grocery shopping behaviors and fruit and vegetable consumption of low-income families participating in the Brighter Bites program in Houston, Texas.
Design: We used a single-group observational study design. We used (1) purposive sampling of schools and (2) convenience sampling of parents/caregivers to recruit participants.
Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking nanoparticles for fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma.
J Nanobiotechnology
December 2024
School of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Cyanine dye-containing nanoparticles have widely been used in "all-in-one" NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modulation methods to tune absorption and emission wavelengths. The combination of good brightness and excellent tumor-targeting capacity is the key to realize efficient NIR-II FI-guided PTT. In this study, by covalently decorating NIR-II absorptive cyanine dyes with bulky AIE motify, we demonstrate how steric hindrance suppresses π-π stacking-induced fluorescence quenching and contributes to the good brightness of NIR-II FI of subcutaneous glioblastoma.
View Article and Find Full Text PDFThe current troubled state of the global pathology workforce: a concise review.
Diagn Pathol
December 2024
Women's Health Research Group, Leeds Institute of Medical Research, St James's University Hospital, University of Leeds, Wellcome Trust Brenner Building, Beckett Street, Leeds, LS9 7TF, UK.
The histopathology workforce is a cornerstone of cancer diagnostics and is essential to the delivery of cancer services and patient care. The workforce has been subject to significant pressures over recent years, and this review considers them in the UK and internationally. These pressures include declining pathologist numbers, the increasing age of the workforce, and greater workload volume and complexity.
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