A chemoselective Pd-mediated carbonylative Negishi-type catalytic protocol for the synthesis of (hetero)aryl ketones is reported. The protocol employs the PEPPSI-IPr precatalyst and CO gas at atmospheric pressure (balloon) to foster the carbonylative coupling between diverse C(sp)-hybridized organozinc reagents and a broad range of aryl iodides, including substrates carrying aldehyde, aniline, phenol, or carboxylic acid groups, and heteroaryls.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.3c00948 | DOI Listing |
Publication Analysis
Top Keywords
aryl iodides
8
functional-group-tolerant pd-catalyzed
4
pd-catalyzed carbonylative
4
carbonylative negishi
4
negishi coupling
4
coupling aryl
4
iodides chemoselective
4
chemoselective pd-mediated
4
pd-mediated carbonylative
4
carbonylative negishi-type
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!