AI Article Synopsis
- The study focuses on drug resistance genes in Plasmodium vivax (Pv) and Plasmodium falciparum (Pf) co-infections misdiagnosed as Pf mono-infections in Cameroon, highlighting an increasing prevalence of non-falciparum malaria.
- A specific mutation in the pvdhps gene (A383G) was identified, and Pv strains showed close genetic similarity to reference strains from Southeast Asia and the Western Pacific.
- No resistance mutations were found in key Pf genes (Pfmdr1 and Pfk13), but mutations were noted in Pfcrt and Pfdhfr-Pfdhps genes, with no G6PD deficiency mutations detected in patients
Article Abstract
Plasmodium falciparum (Pf) is the predominant malaria species in Africa, but growing rates of non-falciparum species such as P. vivax (Pv) have been reported recently. This study aimed at characterizing drug resistance genes, glucose-6-phosphate dehydrogenase gene (G6PD), and phylogenetic patterns of a Pv + Pf co-infection misdiagnosed as a Pf mono-infection in the Far North region of Cameroon. Only one non-synonymous mutation in the pvdhps gene A383G was found. Pv drug resistance gene sequences were phylogenetically closer to the reference SAL-I strain and isolates from Southeast Asia and Western Pacific countries. Analyzing co-infecting Pf revealed no resistance mutations in Pfmdr1 and Pfk13 genes, but mutations in Pfcrt (CVIET) and Pfdhfr-Pfdhps genes (ACIRNL - AAKGS) were observed. No G6PD deficiency-related mutations were found. This is first study from Cameroon reporting presence of putative drug resistance mutations in Pv infections, especially in the pvdhps gene, and also outlined the absence of a G6PD-deficiency trait in patients.
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| http://dx.doi.org/10.1007/s00284-023-03522-7 | DOI Listing |
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