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Draft genome sequence of Kei apple, an underutilized African tree crop.
Sci Data
January 2025
International Livestock Research Institute, P.O. Box 30709, Nairobi, 00100, Kenya.
To address food and nutrition security in the face of burgeoning global populations and erratic climatic conditions there is a need to include nutrient dense, climatic resilient but neglected indigenous fruit trees in agrifood systems. Here we present the draft genome sequence of Kei Apple, Dovyalis afra, a neglected indigenous African fruit tree with untapped potential to contribute to nutrient security and improved livelihoods. Our long-read-based genome assembly comprises 440 Mbp sequence across 1190 contigs with a N50 and L50 of 13.
View Article and Find Full Text PDFUnlocking the potential of chimeric antigen receptor T cell engineering immunotherapy: Long road to achieve precise targeted therapy for hepatobiliary pancreatic cancers.
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January 2025
Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:
Innovative therapeutic strategies are urgently needed to address the ongoing global health concern of hepatobiliary pancreatic malignancies. This review summarizes the latest and most comprehensive research of chimeric antigen receptor (CAR-T) cell engineering immunotherapy for treating hepatobiliary pancreatic cancers. Commencing with an exploration of the distinct anatomical location and the immunosuppressive, hypoxic tumor microenvironment (TME), this review critically assesses the limitations of current CAR-T therapy in hepatobiliary pancreatic cancers and proposes corresponding solutions.
View Article and Find Full Text PDFUnlocking the potential of primary care: addressing systemic challenges in chronic disease prevention.
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Department of Theology and Religious Education, De La Salle University, Manila, Philippines.
Harnessing Internet Search Data as a Potential Tool for Medical Diagnosis: Literature Review.
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December 2024
Innovation Horizons, Inc., 2819 27th Street, NW, Washington, DC, US.
Background: Access to accurate medical diagnosis has been hindered by socioeconomic disparities, limited availability of specialized medical professionals, and lack of patient education, among other factors. Inequities in access to high-quality healthcare services exacerbate these challenges, often leading to disparities in health outcomes. Missed or inaccurate diagnoses can lead to delayed or unnecessary treatments, risking worsening of the condition.
View Article and Find Full Text PDFAll-Optical Single-Channel Plasmonic Logic Gates.
Nano Lett
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State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.
Optical computing, renowned for its light-speed processing and low power consumption, typically relies on the coherent control of two light sources. However, there are challenges in stabilizing and maintaining high optical spatiotemporal coherence, especially for large-scale computing systems. The coherence requires rigorous feedback circuits and numerous phase shifters, introducing system instability and complexity.
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