AI Article Synopsis
- * A total of 37 studies (9 randomized controlled trials and 28 cohort studies) were reviewed, with the cohort studies showing a significant reduction in both systolic and diastolic blood pressure after treatment.
- * The blood pressure-lowering effect of levothyroxine is particularly notable in Caucasians and in SCH patients who start with higher thyroid-stimulating hormone (TSH) levels and have a significant reduction to normal levels.
Article Abstract
This study aims to evaluate the effect of levothyroxine therapy on blood pressure (BP) in patients with subclinical hypothyroidism (SCH). Were searched Six databases, and randomized controlled trials (RCT) and prospective cohort studies evaluating the effect of levothyroxine therapy on BP in patients with SCH were included. 37 articles (9 RCTs and 28 prospective cohorts) were included in this meta-analysis. Pooled analysis of RCT studies was insignificant; however, pooled analysis of 28 prospective cohort studies showed a significant difference before and after the therapy, reducing both systolic blood pressure (SBP) and diastolic blood pressure (DBP) (MD=-4.02 [-6.45, -4.58] and MD=-2.13 [-3.69, -0.56], both P-values<0.05). Levothyroxine therapy can play a role in lowering BP in patients with SCH. However, this effect is more observed in Caucasians, SCH patients with higher initial TSH followed by more remarkable TSH change to normal levels, and SCH patients with hypertension.
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| http://dx.doi.org/10.1016/j.cpcardiol.2023.102204 | DOI Listing |
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