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Objective: To summarize antiretroviral therapy (ART) use in the setting of end-stage kidney disease (ESKD).
Design: Cross-sectional analysis.
Methods: Descriptive analysis of ART regimens and dose of nucleoside/nucleotide reverse-transcriptase inhibitors (NRTI) in people with HIV and ESKD (dialysis, kidney transplantation, or estimated glomerular filtration rate (eGFR) <15 mL/min/1.
Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease.
Toxins (Basel)
December 2024
Graduate Program in Biological Sciences-Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-630, Brazil.
Background: In patients with chronic kidney disease (CKD), trimethylamine n-oxide (TMAO) accumulation exacerbates inflammation and contributes to oxidative stress. These complications are putatively linked to the development of cardiovascular diseases. Despite the known associations, the variation in TMAO plasma levels across different CKD stages and dialysis modalities remains underexplored.
View Article and Find Full Text PDFThe steady-state pharmacokinetics of fixed-dose combination dolutegravir+rilpivirine in hemodialysis.
AIDS
November 2024
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Objective: Fixed dose combination (FDC) dolutegravir (DTG) plus rilpivirine (RPV) is an approved antiretroviral treatment regimen for people with HIV. The steady-state pharmacokinetics (PK) of FDC DTG+RPV in hemodialysis (HD) has not been previously studied.
Design: We performed a single-center, prospective evaluation of the steady-state PK of FDC DTG +RPV in 4 adults without HIV either requiring HD and in 4 matched participants with normal renal function.
Recent advancements in the synthesis of anion exchange membranes and their potential applications in wastewater treatment.
Adv Colloid Interface Sci
February 2025
Department of Chemistry, Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India; Sophisticated Analytical Instrumentation Facility (SAIF)/ Central Instrumentation Laboratory (CIL), Panjab University, Chandigarh 160014, India. Electronic address:
Water treatment procedures are increasingly utilized for resource recovery and wastewater disinfection, addressing the current challenges of clean water depletion and wastewater management. Various pollutants, including dyes, acids, pharmaceuticals, and toxic heavy metals have been released into the environment through industrial, domestic, and agricultural activities, posing serious environmental and public health risks. Addressing these issues requires the development of more effective waste treatment processes.
View Article and Find Full Text PDFImpact of Early Continuous Kidney Replacement Therapy in Patients With Sepsis-Associated Acute Kidney Injury: An Analysis of the MIMIC-IV Database.
J Korean Med Sci
November 2024
Division of Infectious Diseases, Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Renal replacement therapy (RRT) is critical for treating sepsis-related acute kidney injury (AKI), but its ideal timing is debated; this study focused on the effects of starting continuous kidney replacement therapy (CKRT) within 6 hours of AKI onset.
- Analyzing data from the MIMIC-IV database, the study found that patients who received early CKRT had a significantly lower 28-day mortality rate compared to those who started later (26.7% vs. 43.9%).
- Additionally, early CKRT patients experienced more days without needing mechanical ventilation or vasopressors, indicating better overall clinical outcomes despite no significant difference when comparing CKRT initiation within 12 hours versus later.
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